RT Journal Article
T1 Presence and Release of ATP from the Retina in an Alzheimer's Disease Model
A1 Pérez de Lara, María Jesús
A1 Pintor, Jesús
AB The aim of this study was to assess the changes of extracellular ATP levels during the progress of Alzheimer's disease by using a murine model of the disease. Retinal nucleotide release was measured from flattened whole-mounts stimulated with 59 mM KCl or non-stimulated maintained in Ringer solution. Mice exhibited an increase in retinal ATP release as long as the pathology progressed up to 14 months. This value decreased to normal values by 18 months of age. Changes occurred also when comparing to non-pathological mice. The increase in the presence of ATP levels may contribute, together with other factors, to the changes in the functionality of the retina and the concomitant death of retinal cells.
PB IOS Press
SN 1387-2877
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/35444
UL https://hdl.handle.net/20.500.14352/35444
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Salud, Servicios Sociales e Igualdad de España
DS Docta Complutense
RD 5 abr 2025