%0 Journal Article
%A Concellón, José M.
%A Suárez Álvarez, José Ramón
%A García‐Granda, Santiago
%A Díaz, M. Rosario
%T Synthesis and stereoselective lithiation of enantiopure 2‐(1‐aminoalkyl)aziridine–borane complexes
%D 2004
%@ 1433-7851
%U https://hdl.handle.net/20.500.14352/98456
%X This work  shows that the enantiopure 2-(1-aminoalkyl)aziridine–borane complexes can easily be obtained by two alternative methodologies: either reaction with BF3·Et2O followed by reduction with LiAlH4 or by direct reaction with a solution of BH3 in THF. In addition, regio- and stereoselective C3 deuteration or silylation of 2-(1- aminoalkyl)aziridine 1 can be effected by eprotonation/ deuteration or silylation/decomplexation of the corresponding borane complex 2. Application of this methodology to functionalize 2-(1-aminoalkyl)aziridines with other different electrophiles is currently under investigation.
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