RT Journal Article
T1 Synthesis and stereoselective lithiation of enantiopure 2‐(1‐aminoalkyl)aziridine–borane complexes
A1 Concellón, José M.
A1 Suárez Álvarez, José Ramón
A1 García‐Granda, Santiago
A1 Díaz, M. Rosario
AB This work  shows that the enantiopure 2-(1-aminoalkyl)aziridine–borane complexes can easily be obtained by two alternative methodologies: either reaction with BF3·Et2O followed by reduction with LiAlH4 or by direct reaction with a solution of BH3 in THF. In addition, regio- and stereoselective C3 deuteration or silylation of 2-(1- aminoalkyl)aziridine 1 can be effected by eprotonation/ deuteration or silylation/decomplexation of the corresponding borane complex 2. Application of this methodology to functionalize 2-(1-aminoalkyl)aziridines with other different electrophiles is currently under investigation.
PB Wiley-VCH Verlag GmbH & Co
SN 1433-7851
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/98456
UL https://hdl.handle.net/20.500.14352/98456
LA eng
NO Concellón, J. M., Suárez, J. R., García‐Granda, S., & Díaz, M. R. (2004). Synthesis and Stereoselective Lithiation of Enantiopure 2‐(1‐Aminoalkyl) aziridine–Borane Complexes. Angewandte Chemie, 116(33), 4433-4436.
NO Ministerio de Ciencia y Tecnología (España)
DS Docta Complutense
RD 26 abr 2025