RT Journal Article
T1 Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study.
A1 Ruíz Valdepeñas, Lourdes
A1 Martínez Orgado, José Antonio
A1 Benito Villalvilla, Cristina
A1 Millan, África
A1 Tolon, Rosa M.
A1 Romero, Julián
AB Background: The phytocannabinoid cannabidiol (CBD) exhibits antioxidant and antiinflammatory properties. The present study was designed to explore its effects in a mouse model of sepsis-related encephalitis by intravenous administration of lipopolysaccharide (LPS).Methods: Vascular responses of pial vessels were analyzed by intravital microscopy and inflammatory parameters measured by qRT-PCR.Results: CBD prevented LPS-induced arteriolar and venular vasodilation as well as leukocyte margination. In addition, CBD abolished LPS-induced increases in tumor necrosis factor-alpha and cyclooxygenase-2 expression as measured by quantitative real time PCR. The expression of the inducible-nitric oxide synthase was also reduced by CBD. Finally, preservation of Blood Brain Barrier integrity was also associated to the treatment with CBD.Conclusions: These data highlight the antiinflammatory and vascular-stabilizing effects of CBD in endotoxic shock and suggest a possible beneficial effect of this natural cannabinoid.
PB Springer
SN 1742-2094
YR 2011
FD 2011-01-18
LK https://hdl.handle.net/20.500.14352/117129
UL https://hdl.handle.net/20.500.14352/117129
LA eng
NO Ruiz-Valdepeñas, L., Martínez-Orgado, J.A., Benito, C. et al. Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. J Neuroinflammation 8, 5 (2011). https://doi.org/10.1186/1742-2094-8-5
NO CIBERNED
NO Ministerio de Ciencia e Innovación Tecnológica
NO Ministerio de Sanidad (España)
NO Comunidad Autónoma de Madrid
DS Docta Complutense
RD 31 dic 2025