%0 Journal Article
%A Rodríguez García, Alba
%A Mennesson, Nicolas
%A Hernández Ibarburu, Gema
%A Morales, María Luz
%A Garderet, Laurent
%A Bouchereau, Lorine
%A Allain Maillet, Sophie
%A Piver, Eric
%A Marbán, Irene
%A Rubio, David
%A Bigot Corbel, Edith
%A Martínez López, Joaquín
%A Linares Gómez, María
%A Hermouet, Sylvie
%T Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses
%D 2023
%@ 1592-8721
%@ 0390-6078
%U https://hdl.handle.net/20.500.14352/101902
%X Subsets of multiple myeloma (MM) and monoclonal gammopathies of undetermined significance (MGUS) present with a monoclonal immunoglobulin specific for hepatitis C virus (HCV), thus are presumably HCV-driven, and antiviral treatment can lead to the disappearance of antigen stimulation and improved control of clonal plasma cells. Here we studied the role of hepatitis B virus (HBV) in the pathogenesis of MGUS and MM in 45 HBV-infected patients with monoclonal gammopathy. We analysed the specificity of recognition of the monoclonal immunoglobulin of these patients, and validated the efficacy of antiviral treatment (AVT). For 18/45 (40%) HBV-infected patients, the target of the monoclonal immunoglobulin was identified: the most frequent target was HBV (n=11), followed by other infectious pathogens (n=6), and glucosylsphingosine (n=1). Two patients whose monoclonal immunoglobulin targeted HBV (HBx and HBcAg), implying that their gammopathy was HBV-driven, received AVT and the gammopathy did not progress. AVT efficacy was then investigated in a large cohort of HBV-infected MM patients (n=1367), who received anti-HBV treatments, or not, and compared to a cohort of HCV-infected MM patients (n=1220). AVT significantly improved patient probability of overall survival (p=0.016 for the HBV-positive cohort, p=0.005 for the HCV-positive cohort). Altogether, MGUS and MM disease can be HBV- or HCV-driven in infected patients, and the study demonstrates the importance of antiviral treatment in such patients.
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