RT Journal Article
T1 Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses
A1 Rodríguez García, Alba
A1 Mennesson, Nicolas
A1 Hernández Ibarburu, Gema
A1 Morales, María Luz
A1 Garderet, Laurent
A1 Bouchereau, Lorine
A1 Allain Maillet, Sophie
A1 Piver, Eric
A1 Marbán, Irene
A1 Rubio, David
A1 Bigot Corbel, Edith
A1 Martínez López, Joaquín
A1 Linares Gómez, María
A1 Hermouet, Sylvie
AB Subsets of multiple myeloma (MM) and monoclonal gammopathies of undetermined significance (MGUS) present with a monoclonal immunoglobulin specific for hepatitis C virus (HCV), thus are presumably HCV-driven, and antiviral treatment can lead to the disappearance of antigen stimulation and improved control of clonal plasma cells. Here we studied the role of hepatitis B virus (HBV) in the pathogenesis of MGUS and MM in 45 HBV-infected patients with monoclonal gammopathy. We analysed the specificity of recognition of the monoclonal immunoglobulin of these patients, and validated the efficacy of antiviral treatment (AVT). For 18/45 (40%) HBV-infected patients, the target of the monoclonal immunoglobulin was identified: the most frequent target was HBV (n=11), followed by other infectious pathogens (n=6), and glucosylsphingosine (n=1). Two patients whose monoclonal immunoglobulin targeted HBV (HBx and HBcAg), implying that their gammopathy was HBV-driven, received AVT and the gammopathy did not progress. AVT efficacy was then investigated in a large cohort of HBV-infected MM patients (n=1367), who received anti-HBV treatments, or not, and compared to a cohort of HCV-infected MM patients (n=1220). AVT significantly improved patient probability of overall survival (p=0.016 for the HBV-positive cohort, p=0.005 for the HCV-positive cohort). Altogether, MGUS and MM disease can be HBV- or HCV-driven in infected patients, and the study demonstrates the importance of antiviral treatment in such patients.
SN 1592-8721
SN 0390-6078
YR 2023
FD 2023-05-18
LK https://hdl.handle.net/20.500.14352/101902
UL https://hdl.handle.net/20.500.14352/101902
LA eng
NO Rodríguez García, A., Mennesson, N., Hernández Ibarburu, G. et al. «Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses». Haematologica, mayo de 2023. DOI.org (Crossref), https://doi.org/10.3324/haematol.2023.283096.
NO Ligue Nationale contre le Cancer
NO Spanish Society of Hematology
DS Docta Complutense
RD 5 abr 2025