RT Journal Article
T1 Spatiotemporal Distribution and Clinical Characteristics of Zoonotic Tuberculosis, Spain, 2018–2022
A1 Roy, Álvaro
A1 Gómez-Barroso, Diana
A1 Cruz-Ferro, Elena
A1 Fernández, Ana
A1 Martínez-Pino, Isabel
A1 del Henar Marcos, María
A1 Ursúa-Díaz, Isabel
A1 Miras, Susana
A1 Echave, Nuria
A1 Ounarou, Evi
A1 Romero Martínez, Beatriz
A1 Herrera-León, Laura
A1 Herrador, Zaida
AB Zoonotic tuberculosis (zTB) is a communicable disease that has major effects on both human and animal health. Spain reports the highest number of zTB cases in humans annually in the European Union. We describe the epidemiology of human cases of zTB caused by Mycobacterium bovis and M. caprae in Spain during 2018–2022. The incidence of M. bovis infection compared with M. tuberculosis infection was higher in patients who were native-born (adjusted odds ratio [aOR) 2.32, 95% CI 1.44–3.82), HIV-negative (aOR 3.39, 95% CI 1.24–14.0), or had extrapulmonary forms of TB (aOR 2.20, 95% CI 1.46–3.28). The spatial pattern differed by M. tuberculosis complex species; we identified 3 significant clusters of M. bovis and 1 of M. caprae in bovine TB–free regions. Our results show the importance of including animal and human data on circulating zoonotic pathogens under the One Health umbrella.
PB Centers for Disease Control and Prevention
SN 1080-6040
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/122769
UL https://hdl.handle.net/20.500.14352/122769
LA eng
NO Roy, Á., Gómez-Barroso, D., Cruz-Ferro, E., Fernández, A., Martínez-Pino, I., del Henar Marcos, M....Herrador, Z. (2025). Spatiotemporal Distribution and Clinical Characteristics of Zoonotic Tuberculosis, Spain, 2018–2022. Emerging Infectious Diseases, 31(7), 1344-1352. https://doi.org/10.3201/eid3107.250031.
NO Justificación de autores:Z.H., L.H., and B.R. designed the study and prepared the SOPs. A.R., E.O., N.E., and Z.H. performed the statistical analysis. A.R., N.E., and Z.H.wrote the first draft of the manuscript. All the study group contributed to data interpretation, reviewed the manuscript, and approved the final version to be published. L.H. and Z.H. were involved in funding acquisition. L.H. and Z.H. directly accessed and verified the underlying data reported in the manuscript.Contrato postdoctoral Álvaro Roy: CD23CIII/00008
NO Instituto de Salud Carlos III
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 18 dic 2025