RT Journal Article
T1 Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia
T2 Asociación entre el polimorfismo T102C del gen del receptor de serotonina-2A y la esquizofrenia
A1 Saiz-Gonzalez, 
A1 Quintero Gutiérrez Del Álamo, Francisco Javier
A1 Saiz González, María Dolores
A1 Vaquero Lorenzo, Concepcion
A1 Baca-Garcia, Enrique
A1 Diaz-Hernandez, Montserrat
A1 Botillo-Martin, Carlota
A1 Perez-Rodriguez, M Mercedes
A1 Fernandez-Ramos, Carolina
A1 Saiz-Ruiz, Jeronimo
A1 Fernandez Piqueras, Jose
A1 Gonzalez de Rivera, Jose Luis
A1 Leon, Jose de
AB Studies have shown an association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. However, negative findings have also been reported.We conducted a case-control study of the T102C polymorphism in Spanish Caucasians. We compared T102C polymorphism genotypes and allele frequencies in 188 schizophrenia patients and 440 healthy controls.There were significant differences in the distribution of the three genotypes (TT, TC and CC) and in the allele frequencies in controls and schizophrenics. The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C).
PB Elsevier
SN 0278-5846
YR 2006
FD 2006-01-12
LK https://hdl.handle.net/20.500.14352/95571
UL https://hdl.handle.net/20.500.14352/95571
LA eng
NO Vaquero Lorenzo C, Baca-Garcia E, Diaz-Hernandez M, Botillo-Martin C, Perez Rodriguez MM, Fernandez-Ramos C, Saiz-Gonzalez MD, Quintero-Gutierrez FJ, Saiz Ruiz J, Fernandez Piqueras J, Gonzalez de Rivera JL, de Leon J. Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1136-8.
DS Docta Complutense
RD 17 abr 2025