RT Journal Article
T1 Development of Chitosan/Sodium Carboxymethylcellulose Complexes to Improve the Simvastatin Release Rate: Polymer/Polymer and Drug/Polymer Interactions’ Effects on Kinetic Models
A1 López-Manzanara Pérez, Celia
A1 Torres-Pabón, Norma Sofía
A1 Laguna, Almudena
A1 Torrado, Guillermo
A1 Torre Iglesias, Paloma Marina De La
A1 Torrado Durán, Santiago
A1 Torrado Salmerón, Carlos Félix
A2 Papageorgiou, George Z.
AB Simvastatin (SIM) is a potent lipid-lowering drug used to control hyper-cholesterolemia and prevent cardiovascular diseases. SIM presents low oral bioavailability (5%) because of its low aqueous solubility. In this work, polyelectrolyte complexes (PEC) are developed with different chitosan (CS) and carboxymethylcellulose (CMC) ratios that will allow for an increase in the SIM dissolution rate (2.54-fold) in simulated intestinal medium (pH 4.5). Scanning Electron Microscopy (SEM) images revealed highly porous structures. The changes between both complexes, PEC-SIM:CS:CMC (1:1:2) and (1:2:1), were related to the relaxation of the polymer chains upon absorption of the dissolution medium. Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRPD) studies were used to evaluate the polymer/polymer and drug/polymer interactions on the different PEC-SIM:CS:CMC ratios. In addition, the PEC-SIM:CS:CMC (1:2:1) complex exhibited a high ratio of protonated amino groups (NH3+) and an increase in intramolecular hydrogen bonds, which were correlated with a high expansion of the interpolymer chains and an increase in the SIM dissolution rate. Different kinetic models such as zero-order, first-order, Higuchi and Korsmeyer–Peppas were studied to evaluate the influence of CS/CMC ionic interactions on the ability to improve the release rate of poorly soluble drugs.
PB MDPI
SN 2073-4360
YR 2023
FD 2023-10-22
LK https://hdl.handle.net/20.500.14352/92157
UL https://hdl.handle.net/20.500.14352/92157
LA eng
NO LÓPEZ-MANZANARA PÉREZ, Celia, et al. Development of Chitosan/Sodium Carboxymethylcellulose Complexes to Improve the Simvastatin Release Rate: Polymer/Polymer and Drug/Polymer Interactions’ Effects on Kinetic Models. Polymers, 2023, vol. 15, no 20, p. 4184.
NO Ministerio de Ciencia e Innovación, España.
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 7 abr 2025