TY - JOUR AU - Alice Taubes, Alice AU - Nova, Phil AU - Zalocusky, Kelly A. AU - Kosti, Idit AU - Bicak, Mesude AU - Zilberter, Misha Y. AU - Hao, Yanxia AU - Yoon, Seo Yeon AU - Oskotsky, Tomiko AU - Pineda Sanjuan, Silvia AU - Bin Chen, Emily A. AU - Jones, Aery AU - Choudhary, Krishna AU - Grone, Brian AU - Balestra, Maureen E. AU - Chaudhry, Fayzan AU - Paranjpe, Ishan AU - De Freitas, Jessica AU - Koutsodendris, Nicole AU - Chen, Nuo AU - Wang, Celine AU - William Chang, William AU - An, Alice AU - Glicksberg, Benjamin S. AU - Sirota, Marina AU - Huang, Yadong AU - Thuault, Sebastien PY - 2021 DO - 10.1038/s43587-021-00122-7 SN - 2662-8465 UR - https://hdl.handle.net/20.500.14352/96873 T2 - Nature Aging AB - The evident genetic, pathological and clinical heterogeneity of Alzheimer’s disease (AD) poses challenges for traditional drug development. We conducted a computational drug-repurposing screen for drugs to treat apolipoprotein E4 (APOE4)-related AD.... LA - eng M2 - 932 PB - Nature Publishing Group TI - Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease TY - journal article VL - 1 ER -