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T1 Possibilities of using T-cell biophysical biomarkers of ageing
A1 González Bermúdez, Blanca
A1 Abarca Ortega, Aldo
A1 González Sánchez, Mónica
A1 Fuente Del Rey, María Mónica De La
A1 Plaza, Gustavo R.
AB Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete description of the changes at these levels would require extensive measurements of parameters and, furthermore, important fine details of the internal ordering that may be difficult to detect. Therefore, an alternative approach for the characterisation of cells consists of the performance of physical measurements of the whole cell, such as deformability measurements or migration measurements: the physical parameters, complementing the commonly used chemical biomarkers, may contribute to a better understanding of the evolution of T-cell states during ageing. Mechanical measurements, among other biophysical measurements, have the advantage of their relative simplicity: one single parameter agglutinates the complex effects of the variety of changes that gradually appear in cells during ageing.
PB Cambridge University Press
SN 1462-3994
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/133318
UL https://hdl.handle.net/20.500.14352/133318
LA eng
NO González-Bermúdez, B., Abarca-Ortega, A., González-Sánchez, M., De la Fuente, M., & Plaza, G. R. (2022). Possibilities of using T-cell biophysical biomarkers of ageing. Expert Reviews in Molecular Medicine, 24, e35. doi:10.1017/erm.2022.29
NO The authors received support from the Comunidad de Madrid, Spain, grant Tec4Bio-CM/P2018/NMT-4443.
NO Comunidad de Madrid
DS Docta Complutense
RD 19 mar 2026