2026-08-20T17:00:22Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1001742025-10-28T10:06:46Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Rodríguez Rojo, Inmaculada Concepción author Cuesta Prieto, Pablo author López García, María Eugenia author De Frutos Lucas, Jaisalmer author Bruña Fernández, Ricardo author Pereda de Pablo, Ernesto author Barabash Bustelo, Ana author Montejo, Pedro author Montenegro Peña, María Mercedes author Marcos Dolado, Alberto author López-Higes Sánchez, Ramón author Fernández Lucas, Alberto Amable author Maestu Unturbe, Fernando 2024-02-08T08:29:10Z 2024-02-08T08:29:10Z 2018-10-02 Rodríguez-Rojo IC, Cuesta P, López ME, de Frutos-Lucas J, Bruña R, Pereda E, Barabash A, Montejo P, Montenegro-Peña M, Marcos A, López-Higes R, Fernández A, Maestú F. BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females. Front Neurosci. 2018 Oct 2;12:684. doi: 10.3389/fnins.2018.00684 1662-4548 10.3389/fnins.2018.00684 https://hdl.handle.net/20.500.14352/100174 1662-453X https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00684/full 30333719 https://pubmed.ncbi.nlm.nih.gov/30333719/ The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors. eng Attribution 4.0 International BDNF Val66Met polymorphism and gamma band disruption in resting state brain functional connectivity: A magnetoencephalography study in cognitively intact older females journal article 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URL https://docta.ucm.es/bitstreams/f3907216-23d9-4260-bf1c-1d4635d7f5fa/download File MD5 235deb52454bd7e6012f9f2b11dc7ece 1218244 application/pdf Rodríguez-Rojo et al. 2018 Front. Neurosci. 12.684.pdf URL https://docta.ucm.es/bitstreams/0226ea21-b720-4506-a15e-1211de95b5bb/download File MD5 35b03269cf235a30130b942aef790c2b 72315 text/plain Rodríguez-Rojo et al. 2018 Front. Neurosci. 12.684.pdf.txt