2026-06-27T23:54:20Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1002532025-12-19T14:47:07Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Delgado-Alonso, Cristina author Valles-Salgado, Maria author Delgado Álvarez, Alfonso author Yus, Miguel author Gómez-Ruiz, Natividad author Jorquera, Manuela author Polidura, Carmen author Gil, María José author Marcos Dolado, Alberto author Matías-Guiu Guía, Jorge author Matias-Guiu Antem, Jordi author 2022 Objective Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function. Methods Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison. Results COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression. Conclusions Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction. Cristina Delgado-Alonso, Maria Valles-Salgado, Alfonso Delgado-Álvarez, Miguel Yus, Natividad Gómez-Ruiz, Manuela Jorquera, Carmen Polidura, María José Gil, Alberto Marcos, Jorge Matías-Guiu, Jordi A. Matías-Guiu, Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study, Journal of Psychiatric Research, Volume 150, 2022, Pages 40-46, ISSN 0022-3956, https://doi.org/10.1016/j.jpsychires.2022.03.033 0022-3956 10.1016/j.jpsychires.2022.03.033 https://hdl.handle.net/20.500.14352/100253 1879-1379 https://doi.org/10.1016/j.jpsychires.2022.03.033 Cognitive dysfunction associated with COVID-19: a comprehensive neuropsychological study