2026-06-27T11:22:02Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1004132025-03-18T14:59:51Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Aladro, Yolanda author López-Alvarez, Laudino author Sánchez-Reyes, Jorge Mario author Hernández-Tamames, Juan Antonio author Melero Carrasco, Helena author Rubio-Fernández, Sandra author Thuissard, Israel author Cerezo-García, Marta author 2018 Background/objective Two functional networks are proposed as neuronal support for the complex processes of memory: the anterior temporal and the medial posterior systems. We examined the atrophy of hippocampus (HC) and of those areas constituting the two functional memory systems in multiple sclerosis (MS) patients with low disability. Methods Episodic memory (EM) was assessed in 88 relapsing MS patients and in 40 healthy controls using Wechsler Memory Scale III (Spanish adaptation). FreeSurfer software was used to calculate normalized volume of total cortex, grey matter, white matter, subcortical grey matter (thalamus and striatum), HC and both the anterior temporal (entorhinal, ventral temporopolar, lateral orbitofrontal, amygdala) and posterior medial systems (thalamus, parahippocampal, posterior cingulate, precuneus, lateral parietal and medial prefrontal). Linear regression analysis was used to identify predictors of memory performance. Results Total grey matter and cortex volumes correlated with all subtypes of EM, and the precuneus volume correlated with overall, immediate and delayed memories. Univariant regression analysis identified an association between the volumes of the posterior medial memory network regions and EM scores. The volume of the left precuneus area was the unique and independent predictor for all EM subtypes except for visual memory, for which left HC volume was also an independent predictor. Conclusion Left precuneus volume was the best predictor of memory in relapsing MS patients with low disability and mild deficits in EM. Aladro, Y., López-Alvarez, L., Sánchez-Reyes, J.M. et al. Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis. J Neurol 265, 2182–2189 (2018). https://doi.org/10.1007/s00415-018-8965-x 0340-5354 10.1007/s00415-018-8965-x https://hdl.handle.net/20.500.14352/100413 1432-1459 https://doi.org/10.1007/s00415-018-8965-x Relationship between episodic memory and volume of the brain regions of two functional cortical memory systems in multiple sclerosis