2026-06-27T22:46:03Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1007672025-08-28T15:00:53Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Marciello, Marzia author Rossi, Silvia author Caramella, Carla author Remuñán-López, Carmen 2024-02-09T09:38:53Z 2024-02-09T09:38:53Z 2017 Marciello, Marzia, et al. «Freeze-Dried Cylinders Carrying Chitosan Nanoparticles for Vaginal Peptide Delivery». Carbohydrate Polymers, vol. 170, agosto de 2017, pp. 43-51. DOI.org (Crossref), https://doi.org/10.1016/j.carbpol.2017.04.051. 0144-8617 10.1016/j.carbpol.2017.04.051 https://hdl.handle.net/20.500.14352/100767 https://doi.org/10.1016/j.carbpol.2017.04.051 Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines or microbicides to prevent or treat sexually transmitted diseases. In this work, a straightforward and efficient strategy for the vaginal application and release of peptideloaded mucoadhesive nanoparticles was developed. This essentially consists of chitosan nanoparticles encapsulated in suitable hydrophilic freeze-dried cylinders. Chitosan nanoparticles are responsible for carrying the peptide drug and allowing adhesion to the vaginal mucosal epithelium. Hydrophilic freezedried cylinders facilitate the application and quick release of the nanoparticles to the vaginal zone. Upon contact with the aqueous vaginal medium, the excipients constituting these sponge-like systems are quickly dissolved enabling the release of their content. In vitro release studies showed the ability of the sponge-like systems and chitosan nanoparticles to deliver the mucoadhesive nanoparticles and peptide respectively. CLSM micrographs proved the nanoparticles ability promoting the peptide penetration inside the vaginal mucosa. eng Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery journal article 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URL https://docta.ucm.es/bitstreams/960a1383-6430-49e7-ac86-820b686d54b3/download File MD5 8b4a7552a17f07a5d58e908e0ba1e9c2 1254108 application/pdf 13 Freeze-dried cylinders carrying chitosan.pdf