2026-06-27T15:22:48Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1009302025-03-18T12:58:38Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Traba, Javier
author
Sack, Michael
author
Waldmann, Thomas
author
Antón Hurtado, Olga María
2024-02-09T12:48:25Z
2024-02-09T12:48:25Z
2021
Traba, J., Sack, M. N., Waldmann, T. A., & Anton, O. M. (2021). Immunometabolism at the nexus of cancer therapeutic efficacy and resistance. Frontiers in Immunology, 12, 657293.
1664-3224
10.3389/fimmu.2021.657293
https://hdl.handle.net/20.500.14352/100930
https://doi.org/10.3389/fimmu.2021.657293
Constitutive activity of the immune surveillance system detects and kills cancerous cells, although many cancers have developed strategies to avoid detection and to resist their destruction. Cancer immunotherapy entails the manipulation of components of the endogenous immune system as targeted approaches to control and destroy cancer cells. Since one of the major limitations for the antitumor activity of immune cells is the immunosuppressive tumor microenvironment (TME), boosting the immune system to overcome the inhibition provided by the TME is a critical component of oncotherapeutics. In this article, we discuss the main effects of the TME on the metabolism and function of immune cells, and review emerging strategies to potentiate immune cell metabolism to promote antitumor effects either as monotherapeutics or in combination with conventional chemotherapy to optimize cancer management.
eng
Immunometabolism at the nexus of cancer therapeutic efficacy and resistance
journal article
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URL
https://docta.ucm.es/bitstreams/8381f62a-5cda-444e-836d-18cabca2896c/download
File
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Cancer_Therapeutic_Efficacy_and_Resistance.pdf
URL
https://docta.ucm.es/bitstreams/f77e74e1-5fdc-4e00-9715-253f390be2f0/download
File
MD5
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text/plain
Cancer_Therapeutic_Efficacy_and_Resistance.pdf.txt