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oai:docta.ucm.es:20.500.14352/1010502024-02-13T07:58:25Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Mozota, Marta author Castro Navarro, Irma author Gómez Torres, Natalia author Arroyo Rodríguez, Rebeca author Gutiérrez-Díaz, Isabel author Delgado, Susana author Rodríguez Gómez, Juan Miguel author Alba Rubio, Claudio author 2022-12-16 trial showing the beneficial effect of the strain Ligilactobacillus salivarius CECT 30632 (previously known as L. salivarius MP101) on the functional and nutritional status, and on the nasal and fecal inflammatory profiles of elderly residing in a nursing home highly affected by the pandemic. The objective of this post-hoc analysis was to elucidate if there were changes in the nasal and fecal bacteriomes of a subset of these patients as a result of the administration of the strain for 4 months and, also, its impact on their fecal fatty acids profiles. Culture-based methods showed that, while L. salivarius (species level) could not be detected in any of the fecal samples at day 0, L. salivarius CECT 30632 (strain level) was present in all the recruited people at day 120. Paradoxically, the increase in the L. salivarius counts was not reflected in changes in the metataxonomic analysis of the nasal and fecal samples or in changes in the fatty acid profiles in the fecal samples of the recruited people. Overall, our results indicate that L. salivarius CECT 30632 colonized, at least temporarily, the intestinal tract of the recruited elderly and may have contributed to improvements in their functional, nutritional, and immunological status, without changing the general structure of their nasal and fecal bacteriomes when assessed at the genus level. They also suggest the ability of low abundance bacteria to train immunity. Mozota M, Castro I, Gómez-Torres N, Arroyo R, Gutiérrez-Díaz I, Delgado S, Rodríguez JM and Alba C (2022) Administration of Ligilactobacillus salivarius CECT 30632 to elderly during the COVID-19 pandemic: Nasal and fecal metataxonomic analysis and fatty acid profiling. Front. Microbiol. 13:1052675. doi: 10.3389/fmicb.2022.1052675 1664-302X 10.3389/fmicb.2022.1052675 https://hdl.handle.net/20.500.14352/101050 https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1052675/full Administration of Ligilactobacillus salivarius CECT 30632 to elderly during the COVID-19 pandemic: Nasal and fecal metataxonomic analysis and fatty acid profiling