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oai:docta.ucm.es:20.500.14352/1014652025-03-18T11:50:21Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Redondo Martínez, Fernando author Hurtado-Marcos, Carolina author Izquierdo Arias, Fernando author Cuéllar Del Hoyo, María Del Carmen author Fenoy Rodríguez, Soledad author Sáez Álvarez, Yanira author Magnet Dávila, Ángela author Galindo-Regal, Lorena author Uribe, Natalia author López-Bañeres, Manuel author Jiménez, Ana Isabel author Llombart-Cussac, Antonio author Águila De La Fuente, Carmen Del author Andreu-Ballester, Juan Carlos author 2022-10-29 Microsporidia are opportunistic intracellular parasites, generating serious pathology in individuals with a compromised immune system. Infection by microsporidia inhibits p53 and Caspase 3, proteins involved in apoptosis and the cell cycle, which are vital in the malignant process of epithelial cells. The presence of microsporidia in the intestinal tissues of 87 colon cancer (CC) patients and 25 healthy controls was analyzed by real-time PCR and an immunofluorescence antibody test. Anti-Encephalitozoon antibodies were analyzed in serum samples by ELISA (enzyme linked immunosorbent assay). In 36 (41.3%) CC cases, microsporidia infections were identified in their tissues vs. no cases among control subjects (p &lt; 0.0001). An increase in IgG and IgE anti-Encephalitozoon antibodies was found in patients with CC, which would demonstrate continuous and previous contact with the parasite. The high prevalence of microsporidia in tissues and the seroprevalence in patients with CC suggest a relationship between microsporidia and the etiopathogenesis of CC.</jats:p> Redondo F, Hurtado-Marcos C, Izquierdo F, Cuéllar C, Fenoy S, Sáez Y, Magnet Á, Galindo-Regal L, Uribe N, López-Bañeres M, Jiménez AI, Llombart-Cussac A, Del Águila C, Andreu-Ballester JC. Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients. Cancers (Basel). 2022 Oct 29;14(21):5342. doi: 10.3390/cancers14215342. PMID: 36358760; PMCID: PMC9658866. 2072-6694 10.3390/cancers14215342 https://hdl.handle.net/20.500.14352/101465 https://doi.org/10.3390/cancers14215342 Latent Microsporidia Infection Prevalence as a Risk Factor in Colon Cancer Patients