2026-06-28T10:08:10Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1016712025-03-18T14:37:40Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Arcos Navarrete, Daniel
author
Portolés Pérez, María Teresa
2024-02-22T13:20:47Z
2024-02-22T13:20:47Z
2023-01-21
1661-6596
10.3390/ijms24043249
https://hdl.handle.net/20.500.14352/101671
1422-0067
Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including
synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.
eng
Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
journal article
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URL
https://docta.ucm.es/bitstreams/48611703-0959-4758-a2d4-72afc80fcde3/download
File
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119. Int J Mol Sci 2023, 24, 3249.pdf
URL
https://docta.ucm.es/bitstreams/41b58c0f-90d4-4c4b-a4d1-41b9a6278441/download
File
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119. Int J Mol Sci 2023, 24, 3249.pdf.txt