2026-06-07T15:53:21Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1021942025-03-18T14:48:22Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc De Frutos Lucas, Jaisalmer author Cuesta Prieto, Pablo author López Sanz, David author Peral Suárez, África author Cuadrado Soto, Esther author Ramírez Toraño, Federico author Brown, Belinda M. author Serrano, Juan M. author Laws, Simon M. author Rodríguez Rojo, Inmaculada Concepción author Verdejo Román, Juan author Bruña Fernández, Ricardo author Delgado Losada, María Luisa author Barabash Bustelo, Ana author López Sobaler, Ana María author López Sánchez, Ramón author Marcos Dolado, Alberto author Maestu Unturbe, Fernando author 2020-04-24 Background: Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer’s disease (AD) continuum. Conversely, physical activity (PA) has been associated with improved brain health and reduced AD risk. However, there is controversy regarding whether AD genetic risk (in terms of APOE ε4 carriage) modulates these relationships. The utilization of multiple outcome measures within one sample may strengthen our understanding of this complex phenomenon. Method: The relationship between PA and functional connectivity (FC) was examined in a sample of 107 healthy older adults using magnetoencephalography. Additionally, we explored whether ε4 carriage modulates this association. The correlation between FC and brain structural integrity, cognition, and mood was also investigated. Results: A relationship between higher PA and decreased FC (hyposynchrony) in the left temporal lobe was observed among all individuals (across the whole sample, in ε4 carriers, and in ε4 non-carriers), but its effects manifest differently according to genetic risk. In ε4 carriers, we report an association between this region-specific FC profile and preserved brain structure (greater gray matter volumes and higher integrity of white matter tracts). In this group, decreased FC also correlated with reduced anxiety levels. In ε4 non-carriers, this profile is associated with improved cognition (working and episodic memory). Conclusions: PA could mitigate the increase in FC (hypersynchronization) that characterizes preclinical AD, being beneficial for all individuals, especially ε4 carriers. de Frutos-Lucas, J., Cuesta, P., López-Sanz, D., Peral-Suárez, Á., Cuadrado-Soto, E., Ramírez-Toraño, F., Brown, B., Serrano, J. M., Laws, S. M., Rodríguez-Rojo, I. C., Verdejo-Román, J., Bruña, R., Delgado-Losada, M. L., Barabash, A., López-Sobaler, A. M., López-Higes, R., Marcos, A., & Maestú, F. (2020). The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health. Alzheimer's Research & Therapy, 12, 1-12. 1758-9193 10.1186/s13195-020-00608-3 https://hdl.handle.net/20.500.14352/102194 https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00608-3 The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health