2026-06-29T02:48:00Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1022212024-03-15T01:05:04Zcom_20.500.14352_14col_20.500.14352_15

APOE ε4 modulation of training outcomes in several cognitive domains in a sample of cognitively intact older adults López Sánchez, Ramón Rodríguez Rojo, Inmaculada Concepción Prados Atienza, José María Montejo, Pedro Del Río Grande, David Pedro Delgado Losada, María Luisa Montenegro Peña, María Mercedes López Sanz, David Barabash Bustelo, Ana Background: Most research points to the 4 allele of the apolipoprotein E (APOE) gene as the most recognizable genetic risk factor associated with Alzheimer’s disease pathogenesis. It has been also suggested that the APOE 4 allele has a negative influence on cognitive functioning, which begins long before cognitive impairment becomes manifest. However, still, little is known about the APOE 4 interaction with cognitive intervention programs. Objective: The main goal of this study was to explore whether there was a differential APOE genotype modulation effect after cognitive training in different domains, such as language comprehension, executive functions, and memory. Contrary to other studies, hippocampal volume was controlled for. Methods: Fifty older adults (65+ years; 30 women and 20 men) participated in a multi-domain cognitive training that involved 30 sessions taking place over 12 weeks. Half of the participants were APOE 4 carriers. The control group was matched in age, gender, normalized hippocampal volume, cognitive reserve, Mini-Mental State Examination score, and Geriatric Depression Scale-Short Version. Results: The study revealed that there were consistent treatment benefits in complex sentence comprehension (noncanonical sentences and sentences with two propositions), a domain that was not directly trained, but only in the APOE 4 noncarrier group. Conclusion: Genetic profile modulates training outcomes in sentence comprehension. 2024-03-14T11:35:50Z 2024-03-14T11:35:50Z 2024-03-14T11:35:50Z 2017-06-23 journal article https://hdl.handle.net/20.500.14352/102221 1387-2877 1875-8908 10.3233/jad-161014 eng info:eu-repo/grantAgreement/MINECO//PSI2012-38375-C03-03/ES/ELEMENTOS PARA ENTENDER LAS QUEJAS SUBJETIVAS DE MEMORIA EN EL ENVEJECIMIENTO: EFECTOS DEL ENTRENAMIENTO EN TAREAS COGNITIVAS Y EN LA REORGANIZACION DE REDES FUNCIONALES/ info:eu-repo/grantAgreement/MECD//FPU13%2F02064/ES/FPU13%2F02064/ Lopez-Higes, R., Rodríguez-Rojo, I. C., Prados, J. M., Montejo, P., Del-Río, D., Delgado-Losada, M. L., ... & Barabash, A. (2017). APOE ε4 modulation of training outcomes in several cognitive domains in a sample of cognitively intact older adults. Journal of Alzheimer's Disease, 58(4), 1201-1215. http://creativecommons.org/licenses/by-nc/4.0/ open access Attribution-NonCommercial 4.0 International Sage