2026-06-29T07:38:41Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1022352024-09-24T16:22:23Zcom_20.500.14352_14col_20.500.14352_15

Zinc-doped iron oxide nanoparticles as a proton-activatable agent for dose range verification in proton therapy España Palomares, Samuel Espinosa Rodríguez, Andrea Garcia Diez, Miguel Martinez Nouvilas, Victor Sánchez Tembleque Verbo, Víctor Udías Moinelo, José Manuel Valladolid Onecha, Víctor Fraile Prieto, Luis Mario 539.1 Radiotherapy Nanoparticle Proton range verification Proton therapy Iron oxide nanoparticles Zinc Irradiation Prompt gamma radiation Física nuclear 2207 Física Atómica y Nuclear Artículo firmado por 23 autores Proton therapy allows the treatment of specific areas and avoids the surrounding tissues. However, this technique has uncertainties in terms of the distal dose fall-off. A promising approach to studying the proton range is the use of nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) with a hydrodynamic size of 10 nm and stability in serum. Cytotoxicity, defined as half of the surveillance, was 100 μg Zn/mL in the U251 cell line. The effect on clonogenic cell death was tested after X-ray irradiation, which suggested a radioprotective effect of these nanoparticles at low concentrations (1–10 μg Zn/mL). To evaluate the production of positron emitters and prompt-gamma signals, IONP@Zn-cit was irradiated with protons, obtaining prompt-gamma signals at the lowest measured concentration (10 mg Zn/mL). Finally, 67Ga-IONP@Zn-cit showed accumulation in the liver and spleen and an accumulation in the tumor tissue of 0.95% ID/g in a mouse model of U251 cells. These results suggest the possibility of using Zn nanoparticles as proton-activatable agents to verify the range by prompt gamma detection and face the challenges of prompt gamma detection in a specific biological situation, opening different avenues to go forward in this field. Comunidad de Madrid Ministerio de Ciencia e Innovación (España) Agencia Estatal de Investigación (España) Depto. de Estructura de la Materia, Física Térmica y Electrónica Fac. de Ciencias Físicas Instituto de Física de Partículas y del Cosmos (IPARCOS) TRUE pub 2024-03-14T16:13:35Z 2024-03-14T16:13:35Z 2023-09-29 journal article VoR https://hdl.handle.net/20.500.14352/102235 XXXX-XXXX 10.3390/molecules28196874 1420-3049 eng B2017/BMD-3888 PRONTO-CM S2022/BMD-7434 ASAP-CM info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104558RB-I00/ES/RADIOBIOLOGIA EN LA TERAPIA DE PROTONES. BASES PARA LA COMBINACION DE LA TERAPIA DE PROTONES E INMUNOTERAPIA/ TED2021-130592B-I00 Ibáñez-Moragues, M., Fernández-Barahona, I., Santacruz, R., Oteo, M., Luján-Rodríguez, V. M., Muñoz-Hernando, M., ... & Morcillo, M. Á. (2023). Zinc-Doped Iron Oxide Nanoparticles as a Proton-Activatable Agent for Dose Range Verification in Proton Therapy. Molecules, 28(19), 6874. Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf MDPI