2026-06-08T12:40:25Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1023992025-03-18T13:05:13Zcom_20.500.14352_14col_20.500.14352_15

A pan-cancer analysis of tumor-infiltrating B cell repertoires Yu, Katharine Ravoor, Akshay Malats, Núria Pineda Sanjuan, Silvia Sirota, Marina Hojjat-Farsangi, Mohammad 616-006.04 519.22-76 519.8 B cell repertoire Immune repertoire Tumor microenvironment Tumor infiltration TCGA Oncología Investigación operativa (Estadística) 3207.13 Oncología 2404.01 Bioestadística 1207 Investigación Operativa The supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2021.790119/full#supplementary-material Tumor-infiltrating B cells can play an important role in anti-tumor responses but their presence is not well understood. In this study, we extracted the B cell receptor repertoires from 9522 tumor and adjacent non-tumor samples across 28 tumor types in the Cancer Genome Atlas project and performed diversity and network analysis. We identified differences in diversity and network statistics across tumor types and subtypes and observed a trend towards increased clonality in primary tumors compared to adjacent non-tumor tissues. We also found significant associations between the repertoire features and mutation load, tumor stage, and age. Our V-gene usage analysis identified similar V-gene usage patterns in colorectal and endometrial cancers. Lastly, we evaluated the prognostic value of the repertoire features and identified significant associations with survival in seven tumor types. This study warrants further research into better understanding the role of tumor-infiltrating B cells across a wide range of tumor types. 2019 AACR-AstraZeneca Immuno-oncology Research Fellowship Depto. de Estadística y Ciencia de los Datos Fac. de Estudios Estadísticos TRUE pub 2024-03-20T08:43:59Z 2024-03-20T08:43:59Z 2022-01-05 journal article VoR https://hdl.handle.net/20.500.14352/102399 1664-3224 10.3389/fimmu.2021.790119 eng 19-40-12-PINE Yu, K., Ravoor, A., Malats, N., Pineda, S., & Sirota, M. (2021). A pan-cancer analysis of tumor-infiltrating b cell repertoires. Frontiers in Immunology, 12, 790119–790119. open access application/pdf