2026-06-28T10:12:28Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1024282025-03-18T13:47:23Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Nutu, Anisa author García Conde, María author Jiménez Romero, Luis Carlos author Manrique Municio, Alejandro author Calvo Pulido, Jorge author Caso Maestro, Óscar author Marcacuzco Quinto, Alberto Alejandro author García-Sesma Pérez-Fuentes, Álvaro author Abradelo De Usera, Manuel author San Juan Garrido, Rafael author Justo Alonso, Iago author 2019-12-01 Background: One method for increasing the donor pool for orthotopic liver transplantations (OLTs) is to use uncontrolled donation after circulation death (uDCDs). Methods: From January 2006 to December 2016, we performed 75 OLTs using uDCD livers. The control group comprised a sample of 265 OLTs using livers of donations after brain death (DBDs). A comparative study was performed. Results: Of 256 potential uDCD donors cannulated, 75 (29.3%) livers were accepted for OLT. The amount of hemoderivatives transfused was significantly higher in the uDCD group. The rate of primary nonfunction was also significantly higher (P = 0.031) in uDCD recipients (8%) than DBD recipients (1.5%). The overall rate of biliary complications was significantly higher (P = 0.001) in uDCD recipients (23 cases, 30.6%) than DBD recipients (28 cases, 10.6%). In the uDCD group, 1-, 3-, and 5-year patient survival rates were 82.7%, 73%, and 71.5%, respectively; in the DBD group, they were 89%, 83.7%, and 78.8%, respectively (P = 0.180). In the uDCD group, 1-, 3-, and 5-year graft survival rates were 73.3%, 65.1%, and 63.6%, respectively; in the DBD group, they were 87.1%, 81.9%, and 76.5%, respectively (P = 0.013). Multivariate analysis showed that independent risk factors for patient and graft survival were intraoperative transfusion of >6 units of packed red blood cell concentrates and recipients who were older than 60 years. Conclusions: Although graft survival is significantly lower using uDCD livers, 5-year patient survival in recipients of DBD and uDCD livers is similar. After careful selection, the livers of uDCD can be selectively used for OLT. Liver Transplantation Using Uncontrolled Donors After Circulatory Death: A 10-year Single-center Experience. Jiménez-Romero C, Manrique A, Calvo J, Caso Ó, Marcacuzco A, García-Sesma Á, Abradelo M, Nutu A, García-Conde M, San Juan R, Justo I. Transplantation. 2019 Dec;103(12):2497-2505 0041-1337 10.1097/TP.0000000000002780 https://hdl.handle.net/20.500.14352/102428 1534-6080 https://journals.lww.com/transplantjournal/fulltext/2019/12000/liver_transplantation_using_uncontrolled_donors.12.aspx Liver Transplantation Using Uncontrolled Donors After Circulatory Death: A 10-year Single-center Experience.