2026-06-08T04:38:28Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1029952026-02-11T12:17:51Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Sanz Blasco, Rubén
author
Ruiz Sánchez de León, José María
author
Ávila Villanueva, Marina
author
Valentí‐Soler, Meritxel
author
Gómez‐Ramírez, Jaime
author
Fernández Blázquez, Miguel Ángel
2024-04-11T09:29:39Z
2024-04-11T09:29:39Z
2022
1552-52601552-5279
10.1002/alz.12448
https://hdl.handle.net/20.500.14352/102995
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12448
Introduction. The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods. A total of 985 Spanish community‐dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi‐state Markov models were performed to characterize transitions between states through the dementia continuum. Results. The rate of reversion from MCI to NC was 11%. There were significant non‐modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion. Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC.
eng
Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
journal article
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URL
https://docta.ucm.es/bitstreams/26634a07-4776-4584-b1ef-b29a72dc3e96/download
File
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application/pdf
Manuscript_Reversion_from_MCI_to_NC_REVIEW DOCTA.pdf
URL
https://docta.ucm.es/bitstreams/bf0c0b2d-7664-418b-a055-46501f77db41/download
File
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text/plain
Manuscript_Reversion_from_MCI_to_NC_REVIEW DOCTA.pdf.txt