2026-08-20T15:41:01Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1033602025-09-16T14:52:42Zcom_20.500.14352_14col_20.500.14352_15

P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions Nanda, Sourav Lapeña Motilva, José Kumar Misra, Amar Guha, Gautam Ghosh, Sinjan Manna, Akash Roy, Soumit Benito León, Julián 616.8-089.5 P300 Wave Cognitive Performance Cerebellum Neurociencias (Medicina) 3207.11 Neuropatología Abstract Patients with cognitive deficits have a prolonged latency and reduced amplitude of the P300 wave. However, no study has correlated P300 wave alterations with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients was associated with P300 wave alterations. We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery (FAB) were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale (ICARS) for cerebellar signs. We compared the results with the normative data of the Indian population. Patients had P300 wave alterations with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p< 0.001). In closing, patients with cerebellar lesions had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of the ICARS, reinforcing that the cerebellum has motor, cognitive, and affective functions. National Institutes of Health (EEUU) European Commission Ministerio de Ecnomía y Competitividad (España) Fundación Española para la Ciencia y la Tecnología Depto. de Medicina Fac. de Medicina TRUE pub APC financiada por la UCM 2024-04-23T07:21:57Z 2024-04-23T07:21:57Z 2023 journal article VoR https://hdl.handle.net/20.500.14352/103360 1473-4230 10.1007/s12311-023-01570-0 eng info:eu-repo/grantAgreement/MINECO//PI12%2F01602/ES/Cohorte biomédica, cerrada y de origen comunitario integrada con participantes del centro de España. Estudio observacional del temblor esencial y la enfermedad de Parkinson (NEDICES-2)/ info:eu-repo/grantAgreement/MINECO//PI16%2F00451/ES/EVOLUCIÓN CLÍNICA Y RADIOLÓGICA DEL SÍNDROME RADIOLÓGICO AISLADO/ info:eu-repo/grantAgreement/MINECO//RTC2015–3967-1/ES info:eu-repo/grantAgreement/EC/ICT-2011/287739 Nanda S, Lapeña-Motilva J, Misra AK, Guha G, Ghosh S, Manna A, Roy S, Benito-León J. P300 Wave Alterations and Cognitive Impairment in Cerebellum Lesions. Cerebellum. 2023 May 26. doi: 10.1007/s12311-023-01570-0. Epub ahead of print. PMID: 37233909. Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf SpringerLink