2026-06-29T02:40:13Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1033932025-03-18T13:14:05Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Cantero-Bahillo, Emma author Navarro Del Hierro, Joaquín author Siles-Sánchez, María de las Nieves author Jaime, Laura author Santoyo, Susana author Martín, Diana author 2024-02-12 Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts. Cantero-Bahillo, E.; Navarro del Hierro, J.; de las Nieves Siles-Sánchez, M.; Jaime, L.; Santoyo, S.; Martin, D. Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates. Foods 2024, 13, 562. https://doi.org/ 10.3390/foods13040562 2304-8158 10.3390/foods13040562 https://hdl.handle.net/20.500.14352/103393 https://doi.org/10.3390/foods13040562 Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates