2026-06-01T02:23:01Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1035442025-03-18T15:39:42Zcom_20.500.14352_14col_20.500.14352_15

Echocardiographic Assessment of the Pulmonary Vein to Pulmonary Artery Ratio in Canine Heartworm Disease Isidoro Matos, Jorge Caro Vadillo, Alicia Falcón-Cordón, Yaiza García-Rodríguez, Sara Nieves Costa-Rodríguez, Noelia Carretón, Elena Montoya-Alonso, José Alberto 636.7 616.12 Dirofilaria immitis; Heartworm disease Pulmonary vein Pulmonary artery PV:PA ratio RPAD index Pulmonary hypertension Animal diseases Veterinaria 3109 Ciencias Veterinarias Dirofilaria immitis produces proliferative pulmonary endarteritis and pulmonary thromboembolism in infected dogs. The pulmonary vascular lesions lead to irreversible and persistent structural damage and, as a consequence, sustained precapillary pulmonary hypertension (PH). The purpose of this study was to assess the diagnostic value of the pulmonary vein to pulmonary artery ratio (PV:PA ratio) to determine moderate or severe PH (>50 mmHg) in dogs with heartworm disease. Methods: A total of 151 naturally heartworm-infected and 66 healthy dogs were included in the study. The presence/absence of PH was based on the right pulmonary artery distensibility index (RPAD index < 29.5%), and the PV:PA ratio was echocardiographically measured by the time–motion mode (M mode) and two-dimensional mode (2D mode). Other echocardiographic parameters were also assessed (pulmonary trunk to aorta ratio, tricuspid regurgitation pressure gradient, and AT:ET ratio). Results: The results of the PV:PA ratio showed a highly positive correlation between the M and 2D modes (r = 0.928). The PV:PA ratio obtained by the M mode was identified as the strongest predictor for RPAD index (R2 0.628, p < 0.0001) with a good diagnostic accuracy (AUC = 0.99). The results of PV/PA by the 2D mode showed a similar prediction for the RPAD index (R2 0.606, p < 0.0001) with a good diagnostic accuracy (AUC = 0.98). Both of the 2D and M modes’ PV:PA ratios decreased significantly with the presence of PH. A cut-off value of ≤0.845 showed high sensitivity and specificity for the M mode (97% and 94%, respectively) and the 2D mode (96% and 93%, respectively). Conclusions: The PV:PA ratio may be useful as a complementary diagnostic method for the estimation of moderate or severe PH in dogs with heartworm. MERCK SHARP & DOHME ANIMAL HEALTH Gobierno de Canarias Universidad de las Palmas de Gran Canaria Depto. de Medicina y Cirugía Animal Fac. de Veterinaria TRUE pub 2024-04-25T18:27:19Z 2024-04-25T18:27:19Z 2023-02-17 journal article VoR https://hdl.handle.net/20.500.14352/103544 XXXX-XXXX 10.3390/ani13040703 2076-2615 eng CN-240/030/158 TESIS2021010010 PIFULPGC-2017-CCSALUD-3 PIFULPGC-2020-2-CCSALUD-2 Matos, J.I.; Caro-Vadillo, A.; Falcón-Cordón, Y.; García-Rodríguez, S.N.; Costa-Rodríguez, N.; Carretón, E.; Montoya-Alonso, J.A. Echocardiographic Assessment of the Pulmonary Vein to Pulmonary Artery Ratio in Canine Heartworm Disease. Animals 2023, 13, 703. https:// doi.org/10.3390/ani13040703 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf MDPI