2026-08-16T05:36:33Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1036302025-03-18T13:17:21Zcom_20.500.14352_14col_20.500.14352_15

Zapata González, Agustín Gregorio 2024-04-29T11:58:30Z 2024-04-29T11:58:30Z 2023-12-14 1050-4648 10.1016/j.fsi.2023.109280 https://hdl.handle.net/20.500.14352/103630 https://doi.org/10.1016/j.fsi.2023.109280 In the present study, we review the structure and function of fish spleen with special emphasis on its condition in Elasmobranchs, Teleosts and Lungfish. Apart from the amount of splenic lymphoid tissue, the histological organization of the organ ensures the existence of areas involved in antigen trapping, the ellipsoids, and exhibit numerous melano-macrophages which appear isolated or forming the so-called melano-macrophage centres. An extensive discussion on the functional significance of these centres conclude that they are mere accumulations of macrophages consequence of tissue homeostasis rather than primitive germinal centres, as proposed by some authors. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 International The fish spleen journal article