2026-06-27T16:19:28Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1036432025-09-02T12:40:21Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Ramos, Mónica author Quezada-Feijoó, Maribel author Ayala, Rocío author Manzano, Ascensión author Gómez-Pavón, Francisco author Jaramillo, Javier author Herrera, Cristina author López Vazquez de la Torre, Mariola author Toro, Rocío 2024-04-29T16:35:18Z 2024-04-29T16:35:18Z 2023 Ramos, M.; Quezada-Feijoó, M.; Ayala, R.; Manzano, A.; Gómez-Pavón, F.J.; Jaramillo, J.; Herrera, C.; López Vazquez de la Torre, M.; Toro, R. Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis. J. Clin. Med. 2023, 12, 2987. https://doi.org/10.3390/jcm12082987 10.3390/jcm12082987 https://hdl.handle.net/20.500.14352/103643 https://doi.org/10.3390/jcm12082987 https://www.mdpi.com/2077-0383/12/8/2987 Recognizing symptoms in elderly patients with severe aortic stenosis (AS) can be a challenge. Serum biomarkers such as Galectin-3 or N-terminal prohormone B-type natriuretic peptide (NT-proBNP) are involved in remodeling and heart failure (HF) development and could support the diagnosis of AS. We set out to test the usefulness of NT-proBNP and Galectin-3 in predicting events in this population. We designed a prospective observational case–control study, including 50 asymptomatic patients older than 70 years, diagnosed with severe degenerative AS, and 50 control individuals. The NT-proBNP and Galectin-3 levels were measured. A follow-up was carried out at 12 months to determine the occurrence of hospital admission for HF, all-cause mortality or the appearance of symptoms. The patients with severe AS had higher Galectin-3 and NT-proBNP concentrations. The area under the receiver operating characteristic curve of the NT-proBNP was 0.812 (95% CI, 0.646–0.832), and that of the Galectin-3 was 0.633 (95% CI, 0.711–0.913). NT-proBNP was a good predictor of events [HR 3.45 (95% CI 1.32–9.03), p = 0.011]. A Kaplan–Meier analysis showed that the probability of freedom from events was significant in patients who exhibited a combination of higher NT-proBNP and Galectin-3 levels (log-rank p = 0.032). Therefore, NT-proBNP was the most reliable predictor of events in asymptomatic patients with severe AS. A combination of NT-proBNP and Galectin-3 levels may be vital in the clinical follow-up of these patients and in the decision-making process. eng Attribution 4.0 International Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis journal article 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