2026-06-08T23:17:06Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1038892025-12-19T14:55:02Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Cabrera Martín, María Nieves
author
Nespral, Pedro
author
Valles-Salgado, Maria
author
Bascuñana, Pablo
author
Delgado-Alonso, Cristina
author
Delgado Álvarez, Alfonso
author
Fernández-Romero, Lucía
author
López-Carbonero, Juan Ignacio
author
Díez-Cirarda, María
author
Gil-Moreno, María José
author
Matías-Guiu Guía, Jorge
author
Matias-Guiu Antem, Jordi
2024-05-10T10:25:54Z
2024-05-10T10:25:54Z
2023-11
Cabrera-Martín MN, Nespral P, Valles-Salgado M, Bascuñana P, Delgado-Alonso C, Delgado-Álvarez A, Fernández-Romero L, López-Carbonero JI, Díez-Cirarda M, Gil-Moreno MJ, Matías-Guiu J and Matias-Guiu JA (2023) FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration. Front. Psychol. 14:1273608. doi: 10.3389/fpsyg.2023.1273608
1664-1078
10.3389/fpsyg.2023.1273608
https://hdl.handle.net/20.500.14352/103889
https://doi.org/10.3389/fpsyg.2023.1273608
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1273608/full
Introduction: The Addenbrooke’s Cognitive Examination III (ACE-III) is a brief test useful for neuropsychological assessment. Several studies have validated the test for the diagnosis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In this study, we aimed to examine the metabolic correlates associated with the performance of ACE-III in AD and behavioral variant FTD.
Methods: We enrolled 300 participants in a cross-sectional study, including 180 patients with AD, 60 with behavioral FTD (bvFTD), and 60 controls. An 18F-Fluorodeoxyglucose positron emission tomography study was performed in all cases. Correlation between the ACE-III and its domains (attention, memory, fluency, language, and visuospatial) with the brain metabolism was estimated.
Results: The ACE-III showed distinct neural correlates in bvFTD and AD, effectively capturing the most relevant regions involved in these disorders. Neural correlates differed for each domain, especially in the case of bvFTD. Lower ACE-III scores were associated with more advanced stages in both disorders. The ACE-III exhibited high discrimination between bvFTD vs. HC, and between AD vs. HC. Additionally, it was sensitive to detect hypometabolism in brain regions associated with bvFTD and AD.
Conclusion: Our study contributes to the knowledge of the brain regions associated with ACE-III, thereby facilitating its interpretation, and highlighting its suitability for screening and monitoring. This study provides further validation of ACE-III in the context of AD and FTD.
eng
Attribution 4.0 International
FDG-PET-based neural correlates of Addenbrooke’s cognitive examination III scores in Alzheimer’s disease and frontotemporal degeneration
journal article
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CabreraMartin_2023_FrontPsy.pdf