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oai:docta.ucm.es:20.500.14352/1039772025-03-18T13:58:15Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Melero, Verónica author Arnoriaga, Maria author Barabash Bustelo, Ana author Valerio, Johanna author del Valle, Laura author Martín O'Connor, Rocío author De Miguel Novoa, María De La Paz author Díaz Pérez, José Ángel author Familiar, Cristina author Moraga, Inmaculada author Durán Rodríguez-Hervada, Alejandra author Cuesta, Martín author Torrejón, María José author Martínez-Novillo González, Mercedes author Moreno, María author Romera, Gisela author Runkle De La Vega, Isabel Ana author Pazos, Mario author Rubio Herrera, Miguel Ángel author Matía Martín, María Del Pilar author Calle Pascual, Alfonso Luis author 2023-07-22 A Mediterranean diet (MedDiet)-based intervention reduces the rate of immediate postpartum maternal metabolic disorders. Whether these effects persist long-term remains to be determined. A total of 2526 normoglycemic women were randomized before the 12th gestational week (GW). IG women followed a MedDiet with extra virgin olive oil (EVOO) (>40 mL/day) and a handful of nuts daily, whereas CG women had to restrict all kinds of dietary fat. At 3 months postpartum, a motivational lifestyle interview was held. The endpoint of the study evaluated the rate of abnormal glucose regulation (AGR) and metabolic syndrome (MetS) at 3 years postpartum in women of the San Carlos cohort. A total of 369/625 (59%) CG women and 1031/1603 (64.3%) IG women were finally analyzed. At 3 months and 3 years postdelivery, the IG women showed higher adherence to the MedDiet, which was associated with lower values of body mass index (BMI) and lipid and glycemic profiles. Body weight change and waist circumference were lower in the IG women. After applying multiple regression analysis, the ORs (95%CI) resulted in AGR (3.18 (2.48–4.08); p < 0.001)/MetS (3.79 (1.81–7.95); p = 0.001) for women with GDM and higher OR for development of MetS in CG women (3.73 (1.77–7.87); p = 0.001). A MedDiet-based intervention early in pregnancy demonstrated persistent beneficial effects on AGR and MetS rates at 3 years postpartum. Melero, V., Arnoriaga, M., Barabash, A., Valerio, J., Del Valle, L., Martin O'Connor, R., de Miguel, M. P., Diaz, J. A., Familiar, C., Moraga, I., Duran, A., Cuesta, M., Torrejon, M. J., Martinez-Novillo, M., Moreno, M., Romera, G., Runkle, I., Pazos, M., Rubio, M. A., Matia-Martín, P., … Calle-Pascual, A. L. (2023). An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum. Nutrients, 15(14), 3252. https://doi.org/10.3390/nu15143252 10.3390/nu15143252 https://hdl.handle.net/20.500.14352/103977 2072-6643 https://doi.org/10.3390/nu15143252 37513670 An Early Mediterranean-Based Nutritional Intervention during Pregnancy Reduces Metabolic Syndrome and Glucose Dysregulation Rates at 3 Years Postpartum