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Accommodation response and spherical aberration during 1-Year of orthokeratology lens wear and after discontinuation Batres Valderas, Laura Valdés Soria, Gonzalo Romaguera, María Carracedo Rodríguez, Juan Gonzalo 617.7-089.243 681.73 617.753.2 617.713-089.243 Accommodation Orthokeratology Progressive myopia Spherical aberration Óptica y optometría Lentes de contacto 2209.15 Optometría 2209 Óptica 3311.09 Lentes Received 11 October 2023, Revised 21 February 2024, Accepted 1 March 2024, Available online 11 March 2024, Version of Record 16 May 2024. 2023 Acuerdos transformativos CRUE-CSIC Background: To assess accommodation and spherical aberration changes during one year of orthokeratology lens wear and one month after lens cessation. Methods: A prospective, randomized, longitudinal study was conducted on forty-seven young healthy subjects at the Optometry Clinic of the Complutense University of Madrid (Spain). Non-cycloplegic refraction, high and low uncorrected visual acuity, high and low best corrected visual acuity, accommodative lag, horizontal near phoria, corneal topography, and high-order aberrations were performed at baseline, 1-day, 1-week, 1-, 6- and 12-months of lens wear and after one month of wash out period. p < 0.05 was considered as statistically significant. Results: Spherical equivalent refraction (SE) was -3.23 ± 1.57D at baseline and -0.36 ± 0.64D after 12-months of lens wear, while accommodative lag changed from 0.53 ± 0.39D to 0.15 ± 0.29D after one year of lens wear. No significant differences were found when comparing SE at baseline and after one month of lens cessation (p > 0.05). A high correlation was found between the accommodative lag at baseline and after 12 M of lens wear. 22 out of 25 subjects with exophoria at baseline showed a significant reduction in the deviation at 12-months (p < 0.05). Total spherical aberration increased during all visits due to the lens wear (p < 0.05) although internal spherical aberration showed a significant decrease for 1-week, 1-month and 12-month visits (p < 0,05). Conclusion: Orthokeratology lenses may change the accommodative response of the patient as a reduction on accommodative lag on exophoric patients and an overall increase on the internal spherical aberrations was found during treatment but return to nearly baseline values when cessation. Depto. de Optometría y Visión Fac. de Óptica y Optometría TRUE inpress APC financiada por la UCM 2024-05-21T16:38:51Z 2024-05-21T16:38:51Z 2024-03-10 journal article VoR https://hdl.handle.net/20.500.14352/104290 1367-0484 10.1016/j.clae.2024.102133 1476-5411 eng Batres L, Valdes-Soria G, Romaguera M, Carracedo G. Accommodation response and spherical aberration during 1-Year of orthokeratology lens wear and after discontinuation. Cont Lens Anterior Eye. 2024 Mar 10:102133. doi: 10.1016/j.clae.2024.102133. Epub ahead of print. PMID: 38467534. Attribution-ShareAlike 4.0 International http://creativecommons.org/licenses/by-sa/4.0/ open access application/pdf Elsevier