2026-06-29T02:29:35Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1043202024-05-23T00:07:47Zcom_20.500.14352_14col_20.500.14352_15

Docta Complutense author Nielsen, Søren Saxmose author Álvarez Sánchez, Julio author Bicout, Dominique Joseph author Calistri, Paolo author Canali, Elisabetta author Drewe, Julian Ashley author Garin Bastuji, Bruno author Gonzales Rojas, José Luis author Gortázar, Christian author Herskin, Mette S. author Michel, Virginie author Miranda Chueca, Miguel Ángel author Paladino, Bárbara author Roberts, Helen Clare author Spoolder, Hans author Stahl, Carl author Velarde, Antonio author Viltrop, Arvo 2024-05-22T13:21:24Z 2024-05-22T13:21:24Z 2023-10-10 EFSA AHAW Panel (EFSA Panel on Animal Health and Animal Welfare), EuropeanUnion Reference Laboratory for Avian Inﬂuenza, Nielsen, S. S., Alvarez, J., Bicout, D. J., Calistri, P.,Canali, E., Drewe,J. A., Garin-Bastuji, B., Gonzales Rojas, J. L., Gort´azar, C., Herskin, M., Michel, V.,Miranda Chueca, M. A., Padalino, B., Roberts, H. C., Spoolder, H., Stahl, K., Velarde, A., . . . Viltrop, A.2023. Vaccination of poultry against highly pathogenic avian inﬂuenza – part 1. Available vaccines andvaccination strategies. EFSA Journal, 21(10), 1–87. https://doi.org/10.2903/j.efsa.2023.8271 1831-4732 10.2903/j.efsa.2023.8271 https://hdl.handle.net/20.500.14352/104320 https://doi.org/10.2903/j.efsa.2023.8271 37822713 Several vaccines have been developed against highly pathogenic avian influenza (HPAI), mostly inactivated whole-virus vaccines for chickens. In the EU, one vaccine is authorised in chickens but is not fully efficacious to stop transmission, highlighting the need for vaccines tailored to diverse poultry species and production types. Off-label use of vaccines is possible, but effectiveness varies. Vaccines are usually injectable, a time-consuming process. Mass-application vaccines outside hatcheries remain rare. First vaccination varies from in-ovo to 6 weeks of age. Data about immunity onset and duration in the target species are often unavailable, despite being key for effective planning. Minimising antigenic distance between vaccines and field strains is essential, requiring rapid updates of vaccines to match circulating strains. Generating harmonised vaccine efficacy data showing vaccine ability to reduce transmission is crucial and this ability should be also assessed in field trials. Planning vaccination requires selecting the most adequate vaccine type and vaccination scheme. Emergency protective vaccination is limited to vaccines that are not restricted by species, age or pre-existing vector-immunity, while preventive vaccination should prioritise achieving the highest protection, especially for the most susceptible species in high-risk transmission areas. Model simulations in France, Italy and The Netherlands revealed that (i) duck and turkey farms are more infectious than chickens, (ii) depopulating infected farms only showed limitations in controlling disease spread, while 1-km ring-culling performed better than or similar to emergency preventive ring-vaccination scenarios, although with the highest number of depopulated farms, (iii) preventive vaccination of the most susceptible species in high-risk transmission areas was the best option to minimise the outbreaks' number and duration, (iv) during outbreaks in such areas, emergency protective vaccination in a 3-km radius was more effective than 1- and 10-km radius. Vaccine efficacy should be monitored and complement other surveillance and preventive efforts. eng Attribution-NonCommercial-NoDerivatives 4.0 International Vaccination of poultry against highly pathogenic avian influenza – Part 1: Available vaccines and vaccination strategies journal article 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URL https://docta.ucm.es/bitstreams/68bf5fc1-3b19-4d71-ae36-2447d9821d65/download File MD5 510de952aa2aff9c012d0c2686db2075 16420339 application/pdf EFSA Journal - 2023 - - Vaccination of poultry against highly pathogenic avian influenza part 1 Available vaccines and.pdf