2026-06-27T13:59:02Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1045452025-03-18T14:23:29Zcom_20.500.14352_14col_20.500.14352_15

Sánchez Conde, Matilde Alba Rubio, Claudio Castro Navarro, Irma Dronda, Fernando Ramírez, Margarita Arroyo Rodríguez, Rebeca Moreno Guillén, Santiago Rodríguez Gómez, Juan Miguel Brañas Baztán, Fátima Beatriz 2024-05-29T14:19:37Z 2024-05-29T14:19:37Z 2023-08-19 Sánchez-Conde, M.; Alba, C.; Castro, I.; Dronda, F.; Ramírez, M.; Arroyo, R.; Moreno, S.; Rodríguez, J.M.; Brañas, F. Comparison of the Fecal Bacteriome of HIV-Positive and HIV-Negative Older Adults. Biomedicines 2023, 11, 2305. https://doi.org/10.3390/ biomedicines11082305 10.3390/biomedicines11082305 https://hdl.handle.net/20.500.14352/104545 2227-9059 https://doi.org/10.3390/biomedicines11082305 37626801 HIV infection is considered a scenario of accelerated aging. Previous studies have suggested a link between aging, frailty, and gut dysbiosis, but there is a knowledge gap regarding the HIV population. Our objective was to compare the fecal bacteriome of older people with HIV (PWH) and non-HIV controls, and to assess potential links between gut dysbiosis and frailty. A total of 36 fecal samples (24 from PWH and 12 from non-HIV controls) were submitted to a metataxonomic analysis targeting the V3–V4 hypervariable region of the 16S rRNA gene. High-quality reads were assembled and classified into operational taxonomic units. Alpha diversity, assessed using the Shannon index, was higher in the control group than in the HIV group (p < 0.05). The relative abundance of the genus Blautia was higher in the HIV group (p < 0.001). The presence of Blautia was also higher in PWH with depression (p = 0.004), whereas the opposite was observed for the genus Bifidobacterium (p = 0.004). Our study shows shifts in the composition of the PWH bacteriome when compared to that of healthy controls. To our knowledge, this is the first study suggesting a potential link between depression and gut dysbiosis in the HIV population. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Comparison of the Fecal Bacteriome of HIV-Positive and HIV-Negative Older Adults journal article