2026-06-01T02:24:57Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1047242024-06-06T23:49:03Zcom_20.500.14352_14col_20.500.14352_15

Ultrasound Therapy: Experiences and Perspectives for Regenerative Medicine Lucas, Beatriz de Pérez, Laura M. Bernal, Aurora González Gálvez, Beatriz 577.1 577.2 ultrasound clinical trials migration differentiation proliferation stem cells regenerative medicine LIUS Biología molecular (Farmacia) Bioquímica (Farmacia) 32 Ciencias Médicas Ultrasound has emerged as a novel tool for clinical applications, particularly in the context of regenerative medicine. Due to its unique physico-mechanical properties, low-intensity ultrasound (LIUS) has been approved for accelerated fracture healing and for the treatment of established non-union, but its utility has extended beyond tissue engineering to other fields, including cell regeneration. Cells and tissues respond to acoustic ultrasound by switching on genetic repair circuits, triggering a cascade of molecular signals that promote cell proliferation, adhesion, migration, differentiation, and extracellular matrix production. LIUS also induces angiogenesis and tissue regeneration and has anti-inflammatory and anti-degenerative effects. Accordingly, the potential application of ultrasound for tissue repair/regeneration has been tested in several studies as a stand-alone treatment and, more recently, as an adjunct to cell-based therapies. For example, ultrasound has been proposed to improve stem cell homing to target tissues due to its ability to create a transitional and local gradient of cytokines and chemokines. In this review, we provide an overview of the many applications of ultrasound in clinical medicine, with a focus on its value as an adjunct to cell-based interventions. Finally, we discuss the various preclinical and clinical studies that have investigated the potential of ultrasound for regenerative medicine. Ministerio de Ciencia, Innovación y Universidades Depto. de Bioquímica y Biología Molecular Fac. de Farmacia TRUE pub APC financiada por la UCM 2024-06-06T10:44:07Z 2024-06-06T10:44:07Z 2020-09-17 journal article VoR https://hdl.handle.net/20.500.14352/104724 2073-4425 10.3390/genes11091086 eng info:eu-repo/grantAgreement/MINECO//SAF2015-67911-R/ES/DESARROLLO DEL USO DE ULTRASONIDOS PULSADOS PARA MEJORAR LA CAPACIDAD REGENERATIVA DE LAS CELULAS MADRE CARDIACAS/ Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf MDPI