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oai:docta.ucm.es:20.500.14352/1049032024-06-13T23:57:35Zcom_20.500.14352_14col_20.500.14352_15

Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis Fernández de las Peñas, César Plaza Manzano, Gustavo Navarro Santana, Marcos José Olesen, Jes Jensen, Rigmor H. Bendtsen, Lars 615.8 Tension-type headache pressure pain algometer meta-analysis Fisioterapia (Enfermería, Fisioterapia y Podología) 3213.11 Fisioterapia Objective This meta-analysis evaluates pressure pain sensitivity values in symptomatic and distant pain-free areas comparing individuals with tension-type headache to controls. Databases and data treatment Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds in patients with tension-type headache to headache-free controls. Data were extracted by three reviewers. The methodological quality was assessed by the Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (neck) and distant pain-free areas in tension-type headache were compared to headache-free controls. Frequency of tension-type headache and gender were taken into account. Results Twenty studies were included. Patients with tension-type headache exhibited lower pressure pain thresholds than headache-free controls: Trigeminal (MD −49.11 kPa, 95% CI −66.05 to −32.17), cervical spine (MD −88.17 kPa, 95% CI −108.43 to −67.92) and distant pain-free areas (MD −98.43 kPa, 95% CI −136.78 to −60.09). Differences were significant for chronic, episodic, and mixed episodic and chronic tension-type headache within the trigeminal and neck (symptomatic areas), but only significant for chronic tension-type headache (MD −102.86, 95% CI −139.47 to −66.25 kPa) for distant pain-free areas. In general, women had lower pressure pain thresholds than men. The methodological quality ranged from fair (45%) to good (40%). The results showed a high heterogeneity and publication bias. Conclusion This first meta-analysis addressing pressure pain thresholds differences in symptomatic and distant pain-free areas between patients with tension-type headache and controls found low to moderate evidence supporting the presence of pressure pain hypersensitivity in the trigeminal and neck areas in tension-type headache in comparison with headache-free controls. Sensitivity to pressure pain was widespread only in chronic, not episodic, tension-type headache (moderate evidence). Sección Deptal. de Radiología, Rehabilitación y Fisioterapia (Enfermería) Fac. de Enfermería, Fisioterapia y Podología TRUE pub 2024-06-13T14:37:20Z 2024-06-13T14:37:20Z 2020-09-22 journal article VoR https://hdl.handle.net/20.500.14352/104903 0333-1024 1468-2982 10.1177/0333102420958384 eng Fernández-de-Las-Peñas, C., Plaza-Manzano, G., Navarro-Santana, M. J., Olesen, J., Jensen, R. H., & Bendtsen, L. (2021). Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis. Cephalalgia, 41(2), 256-273. metadata only access application/pdf Sage publications