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oai:docta.ucm.es:20.500.14352/1049592024-10-30T17:22:36Zcom_20.500.14352_14col_20.500.14352_15

Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention Galarregui, Cristina Navas Carretero, Santiago Zulet, María Ángeles González Navarro, Carlos J. Martínez, J. Alfredo De Cuevillas, Begoña Marcos Pasero, Helena Aguilar Aguilar, Elena Reglero, Guillermo Ramirez de Molina, Ana Chausa, Paloma Iniesta, Jose M. Hernando, M. Elena Gómez, Enrique J. García Rudolph, Alejandro García Molina, Alberto Loria Kohen, Viviana Constanza Abete, Itziar Elsevier 612.39 Precision nutrition Healthy aging Chronic diseases Functional foods Quality of life Dietética y nutrición (Farmacia) 32 Ciencias Médicas Objectives: Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity. Methods: 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study-between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN-and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months. Results: Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (-4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality. Conclusion: These results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic. Ministerio de Economía, Comercio y Empresa (España) Depto. de Nutrición y Ciencia de los Alimentos Fac. de Farmacia TRUE pub APC financiada por la UCM 2024-06-14T12:07:54Z 2024-06-14T12:07:54Z 2024-06-07 journal article VoR https://hdl.handle.net/20.500.14352/104959 1279-7707 10.1016/j.jnha.2024.100289 eng info:eu-repo/grantAgreement/MINECO//IDI-20160734/ES/ESTRATEGIAS PARA LA MEJORA DE LA CALIDAD DE VIDA DE COLECTIVOS PRE-SENIOR Y SENIOR BASADAS EN LA NUTRICIÓN DE PRECISIÓN (1%2F7)/ Galarregui C, Navas-Carretero S, Zulet MA, González-Navarro CJ, Martínez JA, de Cuevillas B, Marcos-Pasero H, Aguilar-Aguilar E, Reglero G, Ramirez de Molina A, Chausa P, Iniesta JM, Hernando ME, Gómez EJ, Garcia-Rudolph A, García-Molina A, Loria-Kohen V, Abete I. Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention. J Nutr Health Aging. 2024 Jun 11;28(7):100289. doi: 10.1016/j.jnha.2024.100289. Epub ahead of print. PMID: 38865737. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Elsevier