2026-06-08T11:26:06Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1055492025-03-18T13:30:30Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Dumontel, Bianca author Jiménez-Jiménez, Carla author Vallet Regí, María Dulce Nombre author Manzano García, Miguel 2024-07-03T11:50:17Z 2024-07-03T11:50:17Z 2023-12 Bianca Dumontel, Carla Jiménez-Jiménez, María Vallet-Regí, Miguel Manzano, Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems, Materials Today Bio, Volume 23, 2023, 100850 2590-0064 10.1016/j.mtbio.2023.100850 https://hdl.handle.net/20.500.14352/105549 https://doi.org/10.1016/j.mtbio.2023.100850 https://www.sciencedirect.com/science/article/pii/S2590006423003101#section-cited-by In recent years, there has been a breakthrough in the integration of artificial nanoplatforms with natural biomaterials for the development of more efficient drug delivery systems. The formulation of bioinspired nanosystems, combining the benefits of synthetic nanoparticles with the natural features of biological materials, provides an efficient strategy to improve nanoparticle circulation time, biocompatibility and specificity toward targeted tissues. Among others biological materials, extracellular vesicles (EVs), membranous structures secreted by many types of cells composed by a protein rich lipid bilayer, have shown a great potential as drug delivery systems themselves and in combination with artificial nanoparticles. The reason for such interest relays on their natural properties, such as overcoming several biological barriers or migration towards specific tissues. Here, we propose the use of mesoporous silica nanoparticles (MSNs) as efficient and versatile nanocarriers in combination with tumor derived extracellular vesicles (EVs) for the development of selective drug delivery systems. The hybrid nanosystems demonstrated selective cellular internalization in parent cells, indicating that the EV targeting capabilities were efficiently transferred to MSNs by the developed coating strategy. As a result, EVs-coated MSNs provided an enhanced and selective intracellular accumulation of doxorubicin and a specific cytotoxic activity against targeted cancer cells, revealing these hybrid nanosystems as promising candidates for the development of targeted treatments. eng Attribution 4.0 International Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems journal article 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URL https://docta.ucm.es/bitstreams/7bb545f2-bf27-4a88-89fe-495df0ca5866/download File MD5 92ed3fabd6d85022e158fc7fbc2fb8c8 9761297 application/pdf Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems.pdf URL https://docta.ucm.es/bitstreams/50ab86ea-fefc-4313-8316-308eafcb7ed2/download File MD5 302821b1894f69b453baed7a7c8e1076 92857 text/plain Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems.pdf.txt