2026-06-29T02:45:07Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1058622025-09-02T12:03:11Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Perez-Perez, Silvia author Dominguez-Mozo, Maria Inmaculada author Alonso-Gomez, Aitana author Medina, Silvia author Villarubia, Noelia author Fernandez-Velasco, Jose Ignacio author Garcia-Martinez, Maria Angel author Garcia-Calvo, Estefania author Estévez Sánchez, Héctor author Costa-Frossard, Luciene author Alvarez-Cermeño, Jose C. author Luque García, José Luis author Arroyo, Rafael author Villar, Luisa M. author Alvarez-Lafuente, Roberto 2024-07-09T14:52:33Z 2024-07-09T14:52:33Z 2020 Pérez-Pérez S, Domínguez-Mozo MI, Alonso-Gómez A, Medina S, Villarrubia N, Fernández-Velasco JI, García-Martínez MÁ, García-Calvo E, Estévez H, Costa-Frossard L, Alvarez-Cermeño JC, Luque-Garcia JL, Arroyo R, Villar LM, Alvarez-Lafuente R. 2020. Acetate correlates with disability and immune response in multiple sclerosis. PeerJ 8:e10220 https://doi.org/10.7717/peerj.10220 10.7717/peerj.10220 https://hdl.handle.net/20.500.14352/105862 Background. Gut microbiota has been related to multiple sclerosis (MS) etiopathogenesis. Short-chain fatty acids (SCFA) are compounds derived from microbial metabolism that have a role in gut-brain axis. Objectives. To analyse SCFA levels in plasma of MS patients and healthy donors (HD), and the possible link between these levels and both clinical data and immune cell populations. Methods. Ninety-five MS patients and 54 HD were recruited. Patients were selected according to their score in the Expanded Disability Status Scale (EDSS) (49 EDSS ≤ 1.5, 46 EDSS ≥ 5.0). SCFA were studied in plasma samples by liquid chromatography-mass spectrometry. Peripheral blood mononuclear cells were studied by flow cytometry. Gender, age, treatments, EDSS and Multiple Sclerosis Severity Score (MSSS) were evaluated at the recruitment. Results. Plasma acetate levels were higher in patients than in HD (p = 0.003). Patients with EDSS ≥ 5.0 had higher acetate levels than those with EDSS≤ 1.5 (p = 0.029), and HD (p = 2.97e–4). Acetate levels correlated with EDSS (r = 0.387; p = 1.08e–4) and MSSS (r = 0.265;p = 0.011). In untreated MS patients, acetate levels correlated inversely with CD4+ naïve T cells (r = −0.550,p = 0.001) and directly with CD8+ IL-17+ cells (r = 0.557;p = 0.001). Conclusions. Plasma acetate levels are higher in MS patients than in HD. In MS there exists a correlation between plasma acetate levels, EDSS and increased IL-17+ T cells. Future studies will elucidate the role of SCFA in the disease. eng Attribution-NonCommercial-NoDerivatives 4.0 International Acetate correlates with disability and immune response in multiple sclerosis journal article 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URL https://docta.ucm.es/bitstreams/a4aa5790-612b-4572-b21c-a32a0c60c158/download File MD5 1cc3a9bae59ae456e788e83396ebe57d 236689 application/pdf (86) Peer J 8, e10220 (2020).pdf URL https://docta.ucm.es/bitstreams/f7bc5240-1561-4428-8766-8e891f3a9abd/download File MD5 e21c1f31ba23e3ac1840fc4528e4ccaf 42384 text/plain (86) Peer J 8, e10220 (2020).pdf.txt