2026-06-27T16:05:51Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1060432024-07-12T23:59:02Zcom_20.500.14352_14col_20.500.14352_15

Becerro De Bengoa Vallejo, Ricardo Sevillano Fernández, David Alou Cervera, Luis Martín Aragón, Laura Losa Iglesias, Marta Elena Collado Yurrita, Luis Rodolfo Lopez Lopez, Daniel 2024-07-12T12:43:30Z 2024-07-12T12:43:30Z 2018-10 Vallejo RBB, Fernandez DS, Cervera LA, Aragón LM, Iglesias MEL, Yurrita LRC, Lopez DL. Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub: Cross-over trial. Medicine (Baltimore). 2018 Oct;97(42):e12831. 0025-7974 10.1097/md.0000000000012831 https://hdl.handle.net/20.500.14352/106043 1536-5964 http://dx.doi.org/10.1097/MD.0000000000012831 30334981 https://journals.lww.com/md-journal/fulltext/2018/10190/effectiveness_of_surgical_hand_antisepsis_using.44.aspx Background: Chlorhexidine and parachlorometaxylenol (PCMX) are antiseptics recommended for surgical hand antisepsis. To our knowledge, PCMX has not been evaluated for bactericidal efficacy "in vivo. Methods: We conducted a randomized, double-blind, controlled crossover trial to compare the bacterial loads on fingertips and fingernails under laboratory conditions after use of antiseptic test products, including chlorhexidine digluconate 4%, PCMX 3%, and a reference solution of propan-1-ol 60% (P-1). We assessed bacterial load after a prewash with soft soap, immediately after application of an antiseptic, and 3 hours after application and wearing of sterile, powder-free gloves. Our procedures followed those specified by European Norm (EN) 12791 for evaluating surgical hand antiseptics and using cotton swab for fingertips and fingernails. Results: Chlorhexidine digluconate 4% and PCMX 3% did not decrease bacterial load on the hands. The bactericidal performances of chlorhexidine digluconate 4% and PCMX 3% did not differ significantly. Chlorhexidine digluconate 4% and PCMX 3% increased bacterial load on the fingertips after participants had worn gloves for 3 hours. Fingernails had greater bacterial loads than skin on the fingertips. Conclusions: Chlorhexidine digluconate 4% and PCMX 3% had similar bactericidal efficacy, but they failed to meet the EN 12791 efficacy standard. Fingernails should be a particular focus of antisepsis in preparation for surgery.The trial was registered at ClinicalTrials.gov (ID: NCT02500758). eng http://creativecommons.org/licenses/by-nc/4.0/ open access Attribution-NonCommercial 4.0 International Effectiveness of surgical hand antisepsis using chlorhexidine digluconate and parachlorometaxylenol hand scrub journal article