2026-06-29T07:47:25Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1060862025-03-18T13:31:39Zcom_20.500.14352_14col_20.500.14352_15

A New Biocompatible and Antibacterial Phosphate Free Glass-Ceramic for Medical Applications Cabal, Belén Alou Cervera, Luis Cafini, Fabio Couceiro, Ramiro Sevillano Fernández, David Esteban Tejeda, Leticia Guitián, Francisco Torrecillas, Ramón Moya, José S. 611.02 Microbiología médica 2414 Microbiología In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility. Ministerio de Economía y Competitividad (España) Consejo Superior de Investigaciones Científicas (España) Depto. de Medicina Fac. de Medicina TRUE pub 2024-07-15T09:45:42Z 2024-07-15T09:45:42Z 2014-06-25 journal article VoR https://hdl.handle.net/20.500.14352/106086 2045-2322 10.1038/srep05440 eng info:eu-repo/grantAgreement/MINECO/MAT2012/38645 info:eu-repo/grantAgreement/CSIC//201360E012 Cabal B, Alou L, Cafini F, Couceiro R, Sevillano D, Esteban-Tejeda L, Guitián F, Torrecillas R, Moya JS. A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications. Sci Rep. 2014 Jun 25;4:5440. Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ open access application/pdf Nature