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oai:docta.ucm.es:20.500.14352/1068142025-03-18T12:43:32Zcom_20.500.14352_14col_20.500.14352_15

A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection Andreu-Ballester, Juan Carlos Galindo-Regal, Lorena Cuéllar Del Hoyo, María Del Carmen López-Chuliá, Francisca García-Ballesteros, Carlos Fernández-Murga, Leonor Llombart-Cussac, Antonio Domínguez-Márquez, María Victoria Klasse, P. J. Mostafa, Mai 579.6 615.28 576.8 SARS-CoV-2 vaccine antibodies αβ T cells γδ T cells Microbiología (Farmacia) Parasitología (Farmacia) 32 Ciencias Médicas 3207.12 Parasitología Background: The COVID-19 pandemic is the biggest global health problem in the last hundred years. The efficacy of the vaccine to protect against severe disease is estimated to be 70–95% according to the studies carried out, although there are aspects of the immune response to the vaccine that remain unclear. Methods: Humoral and cellular immunity after the administration of three doses of the Pfizer–BioNTech and Oxford AstraZeneca vaccines against SARS-CoV-2 over one year and the appearance of post-vaccination COVID-19 were studied. SARS-CoV-2 IgG and IgA antibodies, αβ and γδ T-cell subsets, and their differentiation stages and apoptosis were analyzed. Results: Anti-SARS-CoV-2 IgG and IgA antibodies showed a progressive increase throughout the duration of the study. This increase was the greatest after the third dose. The highest levels were observed in subjects who had anti-SARS-CoV-2 antibodies prior to vaccination. There was an increase in CD4+ αβ, CD8+ γδ and TEM CD8+ γδ T cells, and a decrease in apoptosis in CD4+ CD8+ and CD56+ αβ and γδ T cells. Post-vaccination SARS-CoV-2 infection was greater than 60%. The symptoms of COVID-19 were very mild and were related to a γδ T cell deficit, specifically CD8+ TEMRA and CD56+ γδ TEM, as well as lower pre-vaccine apoptosis levels. Conclusions: The results unveil the important role of γδ T cells in SARS-CoV-2-vaccine-mediated protection from the disease. REACT-EU programme Consellería de Sanitat Universal i Salut Pública (Generalitat Valenciana, Spain) Depto. de Microbiología y Parasitología Fac. de Farmacia TRUE pub Pagado por el autor 2024-07-17T11:36:49Z 2024-07-17T11:36:49Z 2024-05-18 journal article VoR https://hdl.handle.net/20.500.14352/106814 2076-393X 10.3390/vaccines12050553 eng Andreu-Ballester, Juan Carlos, et al. «A Low Number of Baselines Γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection». Vaccines, vol. 12, n.o 5, mayo de 2024, p. 553. www.mdpi.com, https://doi.org/10.3390/vaccines12050553. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf MDPI