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oai:docta.ucm.es:20.500.14352/1070562025-03-18T15:21:48Zcom_20.500.14352_14col_20.500.14352_15

In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin Alou Cervera, Luis Cafini, Fabio Sevillano Fernández, David Unzueta, Irune Prieto Prieto, José 611.02 Prophylaxis Catheters Vascular-graft infection Microbiología médica 2414 Microbiología Mupirocin and amoxicillin-clavulanate were synergistic against 9 of 49 (18%) strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (CNS). A pattern of enhanced killing was also found using time-kill studies. Time-kill assays were more discriminatory than chequerboard titration assays in demonstrating synergy. These results suggest that combinations of amoxicillin-clavulanate and mupirocin may have therapeutic benefits in prophylaxis against staphylococcal infections. Depto. de Medicina Fac. de Medicina TRUE pub 2024-07-23T12:14:49Z 2024-07-23T12:14:49Z 2004-05 journal article VoR https://hdl.handle.net/20.500.14352/107056 0924-8579 10.1016/j.ijantimicag.2003.09.030 eng Alou L, Cafini F, Sevillano D, Unzueta I, Prieto J. In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin. Int J Antimicrob Agents. 2004 May;23(5):513-6. restricted access application/pdf Elsevier