2026-06-27T11:09:29Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1071292024-07-24T23:56:06Zcom_20.500.14352_14col_20.500.14352_15
Sevillano Fernández, David
Aguilar, Lorenzo
Alou Cervera, Luis
Gimenez, María José
Torrico, Martha
González Hidalgo, Natalia
Cafini, Fabio
Relaño, María Teresa
Coronel, Pilar
Prieto Prieto, José
2024-07-24T12:51:01Z
2024-07-24T12:51:01Z
2008-03
Sevillano D, Aguilar L, Alou L, Giménez M, Torrico M, González N, Cafini F, Relaño M, Coronel P, Prieto J 2008. Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil. Antimicrob Agents Chemother 52:. https://doi.org/10.1128/aac.01247-07
0066-4804
10.1128/aac.01247-07
https://hdl.handle.net/20.500.14352/107129
1098-6596
https://doi.org/10.1128/aac.01247-07
https://journals.asm.org/doi/10.1128/aac.01247-07
Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.
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Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil
journal article