2026-06-27T23:02:03Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1071522024-07-29T23:46:24Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Sevillano Fernández, David author Aguilar, Lorenzo author Alou Cervera, Luis author Giménez, María José author González Hidalgo, Natalia author Echeverría, Olatz author Torrico, Martha author Valdes, Laura author Coronel, Pilar author Prieto Prieto, José 2024-07-29T08:42:13Z 2024-07-29T08:42:13Z 2008 Sevillano D, Aguilar L, Alou L, Giménez MJ, González N, Echeverría O, Torrico M, Valdes L, Coronel P, Prieto J. Beta-lactam activity against penicillin-resistant Streptococcus pneumoniae strains exhibiting higher amoxicillin versus penicillin minimum inhibitory concentration values: an in vitro pharmacodynamic simulation. Chemotherapy. 2008;54(2):84-90. 0009-3157 10.1159/000118659 https://hdl.handle.net/20.500.14352/107152 1421-9794 https://doi.org/10.1159/000118659 https://karger.com/che/article/54/2/84/66258/Lactam-Activity-against-Penicillin-Resistant Background: Activity of simulated serum concentrations after oral therapy with 400 mg cefditoren pivoxil b.i.d., 500 mg cefuroxime axetil b.i.d. and 875/125 mg amoxicillin/clavulanic acid b.i.d. and t.i.d. regimens was explored over 24 h against Streptococcus pneumoniae.Methods: Computerized pharmacodynamic simulations were performed against strains with penicillin/amoxicillin/cefuroxime/cefditoren minimum inhibitory concentrations (MICs, µg/ml) and serotypes: strain 1 (0.25/0.12/1/0.12; serotype 6A), strain 2 (2/4/ 2/0.25; serotype 6B), strain 3 (4/16/4/0.5; serotype 14), and strain 4 (4/16/8/1; serotype 14). Results: Bactericidal activity (≧3 log10 reduction) at 12 and 24 h was obtained against all strains with cefditoren, against strains 1 and 2 with cefuroxime and amoxicillin/clavulanic acid t.i.d., but only against strain 1 with amoxicillin/clavulanic acid b.i.d.. Bactericidal activity at 24 h was related to T > MIC of >30% dosing interval, 1.7–2.0 log10 reductions with T > MIC of 20–30%, and <1 log10 reduction or regrowth with T > MIC of 0%. Conclusions: It is difficult to achieve pharmacodynamic coverage and bactericidal activity by physiological concentrations of oral β-lactams against penicillin-resistant pneumococcal strains exhibiting higher amoxicillin versus penicillin MICs. Cefditoren may offer alternatives. eng β-Lactam Activity against Penicillin-Resistant Streptococcus pneumoniae Strains Exhibiting Higher Amoxicillin versus Penicillin Minimum Inhibitory Concentration Values: An in vitro Pharmacodynamic Simulation journal article 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URL https://docta.ucm.es/bitstreams/329914de-a657-4546-88db-102ae2f39343/download File MD5 117063ed1ffcb26864b02a367ed81238 253129 application/pdf 2008 Chemotherapy - Sevillano -Cefditoren.pdf