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oai:docta.ucm.es:20.500.14352/1071872025-03-18T11:57:18Zcom_20.500.14352_14col_20.500.14352_15

Bactericidal activity of moxifloxacin against multidrug-resistant Streptoccocus pneumoniae at clinically achievable serum and epithelial lining fluid concentrations compared with three other antimicrobials Cafini, Fabio Alou Cervera, Luis Sevillano Fernández, David Valero, Eva Prieto Prieto, José 611.02 Serum Epithelial lining fluid Bactericidal Stationary Logarithmic Microbiología médica 2414 Microbiología Time-kill studies compared the activities of moxifloxacin with those of levofloxacin, azithromycin and amoxicillin-clavulanate against 10 pneumococcal strains with various drug susceptibilities. Three Streptococcus pneumoniae strains were resistant to moxifloxacin: 6, 7 and 2 strains were resistant to levofloxacin, azithromycin and amoxicillin-clavulanate, respectively. Of these, 1 strain was resistant to all antimicrobial agents studied. Moxifloxacin and amoxicillin-clavulanate were bactericidal after 24h at serum Cmax levels against 9 and 8 strains, respectively, while levofloxacin and azithromycin were bactericidal against 3 and 2 strains, respectively. A higher activity was only observed for amoxicillin-clavulanate for logarithmic phase cultures at 1, 4 and 8h compared with stationary phase organisms. Amoxicillin-clavulanate and moxifloxacin were bactericidal at free serum levels (protein unbound) after 24h against 8 and 3 strains, respectively. Moxifloxacin was bactericidal at epithelial lining fluid levels against all strains at 24h, including one moxifloxacin, amoxicillin-clavulanate and azithromycin-resistant strain; lower levels of bactericidal activity was observed for levofloxacin, azithromycin and amoxicillin-clavulanate against 7, 2 and 4 strains, respectively. This demonstrated the importance of moxifloxacin tissue levels. Bayer Depto. de Medicina Fac. de Medicina TRUE pub 2024-07-29T12:16:53Z 2024-07-29T12:16:53Z 2004-10 journal article VoR https://hdl.handle.net/20.500.14352/107187 0924-8579 10.1016/j.ijantimicag.2004.04.015 eng Cafini F, Alou L, Sevillano D, Valero E, Prieto J; Spanish Pneumococcal Infection Study Network (G03/103). Bactericidal activity of moxifloxacin against multidrug-resistant Streptoccocus pneumoniae at clinically achievable serum and epithelial lining fluid concentrations compared with three other antimicrobials. Int J Antimicrob Agents. 2004 Oct;24(4):334-8. restricted access application/pdf Elsevier