2026-06-07T13:54:47Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/107462023-09-13T06:40:52Zcom_20.500.14352_14col_20.500.14352_22
Docta Complutense
advisor
Gómez Gallego, María del Mar
advisor
Casarrubios Palomar, Luis
advisor
Sierra Rodríguez, Miguel Ángel
author
Durán Merinero, Alba
2023-06-17T11:07:02Z
2023-06-17T11:07:02Z
2019-12-12
https://hdl.handle.net/20.500.14352/10746
La presente tesis doctoral se basa en el desarrollo de metodologías que permitan preparar estructuras que combinen metales de transición y biomoléculas. El trabajo se divide en dos partes claramente diferenciadas. Síntesis de miméticos de [FeFe]-hidrogenasas. Las [FeFe]-hidrogenasas son metaloenzimas esenciales en el metabolismo de ciertos microorganismos para la producción de H2. Los miméticos de [FeFe]-hidrogenasas han sido ampliamente estudiados en los últimos años y se han diseñado buscando la similitud estructural de sus centros activos con los complejos de tipo [(μ-SR)2Fe2(CO)6] de las metaloenzimas naturales, en particular los que presentan puentes azaditiolato (ADT) entre los átomos de azufre...The main objective of this PhD thesis is the development of methodologies for the synthesis of structures combining transtition metal complexes and biomolecules. The work has been divided into 2 clearly differenciated parts. 1. Synthesis of [FeFe]-hydrogenase mimics. The mimics of these type of metaloenzymes, a very important class of enzymes related to the production of H2 in the metabolism of certain microorganisms, have been widely studied in the recent years, specially the ones with an aminodithiolate functionality in their structure like the one shown in Figure 1, due to the structural similarity of their active site and complexes like [(μ-SR)2Fe2(CO)6]. the redox properties asociated with the ADT-[FeFe] nucleus, regardless of the complexity of the structure incorporated through the cycloaddition reaction...
spa
Síntesis de sistemas polimetálicos biofuncionales
doctoral thesis
URL
https://docta.ucm.es/bitstreams/3626fa56-4498-46be-9216-621ceb242f3e/download
File
MD5
efe3201b852ff6be655424c254ea82ed
5333491
application/pdf
T41536.pdf
URL
https://docta.ucm.es/bitstreams/0136ad5c-6cb1-4bc7-be98-ab493a851fb1/download
File
MD5
5133bae10553260860b3005ca5b361a5
301679
text/plain
T41536.pdf.txt