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Interaction between acetylsalicylic acid and a cationic amphiphile model: an experimental approach using surface techniques Flores-Sánchez, R. Bigorra-Mir, M. Gámez, F. Lopes-Costa, T. Argudo, P. G. Martín-Romero, M. T. Camacho, L. Pedrosa, J. M. 544 Drug–lipid interaction Langmuir monolayer Brewster angle microscopy Reflection spectroscopy Química física (Química) 2307 Química Física Mechanical and morphological effects of monolayers of octadecylamine upon aspirin adsorption are monitored by Langmuir isotherms measurements and Brewster angle microscopy. Aspirin induced a notable expansion of the corresponding isotherms and a concentration-dependence of the mechanical stability of the films as a consequence of the subtle balance between the solubility of the amine and the monolayer stabilization induced by the ion-pairs, as corroborated by Brewster Angle Microscopy images. The incorporation of the aspirin into the interface was confirmed by UV–vis reflection spectroscopy. Some comments on the feasibility of using aliphatic amines for drug delivery of anionic species are presented. Depto. de Química Física Fac. de Ciencias Químicas TRUE pub APC financiada por la UCM 2024-09-09T10:20:18Z 2024-09-09T10:20:18Z 2023 journal article VoR https://hdl.handle.net/20.500.14352/108013 0009-2614 10.1016/j.cplett.2023.140450 eng R. Flores-Sánchez, M. Bigorra-Mir, F. Gámez, T. Lopes-Costa, P.G. Argudo, M.T. Martín-Romero, L. Camacho, J.M. Pedrosa, Interaction between acetylsalicylic acid and a cationic amphiphile model: An experimental approach using surface techniques, Chemical Physics Letters, Volume 819, 2023, 140450, ISSN 0009-2614, https://doi.org/10.1016/j.cplett.2023.140450. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Elsevier