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oai:docta.ucm.es:20.500.14352/1086762024-10-07T23:49:25Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Agea Martínez, M. author Navarro Cuéllar, Ignacio author Sada Urmeneta, A. author Alijo Serrano, F. author Navarro Cuéllar, Carlos author 2021-09-02 Neuroendocrine carcinomas (NEC) are a group of malignant neoplasms usually located in the lungs or gastrointestinal tract. Fewer cases are located in the head and neck, and in these rare presentations, the lingual tonsil, larynx, and major salivary glands are the most frequently affected sites. NECs exhibit similar characteristics regardless of where they arise. However, because these neoplasms are rare, a clear understanding of their aetiopathogenesis has yet to be described, and options for treatment have varied and are not unified. A rare NEC of the floor of the mouth is reported here; it appears that this location has not been reported previously. The diagnosis was established through histopathological analysis, and the patient underwent systemic treatment. He had a partial response to treatment in the first 3 months, but died 6 months after the initial diagnosis. This highly uncommon tumour can pose a significant diagnostic challenge for clinicians and pathologists alike and can result in diagnostic delay. Agea Martínez M, Navarro Cuéllar I, Sada Urmeneta A, Alijo Serrano F, Navarro Cuéllar C. Large cell neuroendocrine carcinoma on the floor of the mouth: a rare entity in an unusual location. Int J Oral Maxillofac Surg. 2022 Jun;51(6):742-745. doi: 10.1016/j.ijom.2021.08.021. Epub 2021 Sep 2. PMID: 34481737. 0901-5027 10.1016/j.ijom.2021.08.021 https://hdl.handle.net/20.500.14352/108676 1399-0020 https://doi.org/10.1016/j.ijom.2021.08.021 https://www.sciencedirect.com/science/article/pii/S0901502721003131 Large cell neuroendocrine carcinoma on the floor of the mouth: a rare entity in an unusual location